The physiological and clinical significance of nonlinear TCD waveform analysis in occlusive cerebrovascular disease

H. F. Visee, R. W M Keunen, H. C. Pijlman, J. H R Vliegen, D. L J Tavy, K. J. Stam, Cole A. Giller

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In order to compare the results of nonlinear analysis of hemodynamically compromised and noncompromised cerebral circulations we measured consecutive transcranial Doppler (TCD) waveforms of fourteen patients with a unilateral or bilateral occlusion of the internal carotid artery. The cerebral vasomotor reactivity (VMR) to acetazolamide in both middle cerebral artery (MCA) territories was established by using TCD. Conventional TCD data and nonlinear TCD analysis of data were compared. Nonlinear analysis of the TCD time series suggested dynamical chaos based on the fractal dimension of the TCD curve and the positive Lyapunov exponents in the compromised and noncompromised MCA territories. In the areas with the compromised circulation the positive Lyapunov exponents were significantly lower compared to the noncompromised side and in some cases with a negative VMR, the Lyapunov exponent was almost zero. The latter is suggestive for periodic behavior of the impaired cerebral circulation instead of the dynamical chaos which is found under normal conditions. The TCD time series of a hemodynamic compromised cerebral territory not only shows phenomena related to a decreased perfusion pressure (such as a 'damped waveform') but also phenomena which are related to a more prominent periodicity. We speculate that conventional and nonlinear TCD analysis could be used to determine the VMR.

Original languageEnglish (US)
Pages (from-to)384-388
Number of pages5
JournalNeurological Research
Volume17
Issue number5
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Cerebrovascular Disorders
Middle Cerebral Artery
Fractals
Acetazolamide
Internal Carotid Artery
Periodicity
Perfusion
Hemodynamics
Pressure

Keywords

  • cerebral blood flow
  • cerebral hypoperfusion
  • nonlinear analysis
  • occlusive cerebrovascular disease
  • Transcranial Doppler

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Visee, H. F., Keunen, R. W. M., Pijlman, H. C., Vliegen, J. H. R., Tavy, D. L. J., Stam, K. J., & Giller, C. A. (1995). The physiological and clinical significance of nonlinear TCD waveform analysis in occlusive cerebrovascular disease. Neurological Research, 17(5), 384-388.

The physiological and clinical significance of nonlinear TCD waveform analysis in occlusive cerebrovascular disease. / Visee, H. F.; Keunen, R. W M; Pijlman, H. C.; Vliegen, J. H R; Tavy, D. L J; Stam, K. J.; Giller, Cole A.

In: Neurological Research, Vol. 17, No. 5, 01.01.1995, p. 384-388.

Research output: Contribution to journalArticle

Visee, HF, Keunen, RWM, Pijlman, HC, Vliegen, JHR, Tavy, DLJ, Stam, KJ & Giller, CA 1995, 'The physiological and clinical significance of nonlinear TCD waveform analysis in occlusive cerebrovascular disease', Neurological Research, vol. 17, no. 5, pp. 384-388.
Visee HF, Keunen RWM, Pijlman HC, Vliegen JHR, Tavy DLJ, Stam KJ et al. The physiological and clinical significance of nonlinear TCD waveform analysis in occlusive cerebrovascular disease. Neurological Research. 1995 Jan 1;17(5):384-388.
Visee, H. F. ; Keunen, R. W M ; Pijlman, H. C. ; Vliegen, J. H R ; Tavy, D. L J ; Stam, K. J. ; Giller, Cole A. / The physiological and clinical significance of nonlinear TCD waveform analysis in occlusive cerebrovascular disease. In: Neurological Research. 1995 ; Vol. 17, No. 5. pp. 384-388.
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