The potential role of periovarian fat and leptin in initiation of puberty in the immature rat

W. E. Cannady, D. W. Brann, V. B. Mahesh

Research output: Contribution to journalArticle

13 Scopus citations


Twenty-four-day old female rats were injected with 25 μg recombinant leptin twice daily for 24, 48, 72, or 93 h. Periovarian fat contained significantly greater amounts of aromatase mRNA at 72 and 93 h and estradiol at 72 h after leptin treatment as compared to the ovary. On the other hand, there was an increase in testosterone at 72 h and progesterone at 72 and 93 h after leptin in the ovary as compared to periovarian fat. Cholesterol side chain cleavage and 17α-hydroxylase mRNA were found only in the ovary and not periovarian fat. Thus, periovarian fat has a greater capacity to synthesize estrogen than the ovary in the immature rat and adipose tissue may serve as the primary source of estrogen in the prepubertal period which results in the onset of puberty.

Original languageEnglish (US)
Pages (from-to)S146-S147
JournalInternational Journal of Obesity
Publication statusPublished - Jun 2000



  • Estradiol
  • Leptin
  • Ovary
  • Periovarian fat
  • Puberty

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this