The prevalence of androgen excess among patients with minimal unwanted hair growth

Irene Souter, Luis A. Sanchez, Marilda Perez, Alfred A. Bartolucci, Ricardo Azziz

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The prevalence of androgen excess (AE) and the value of preemptive endocrine evaluation in women with minimal unwanted hair growth are unclear. A total of 228 patients presented with minimal unwanted hair growth and a mF-G score of 5 or less. Total and free testosterone, dehydroepiandrosterone sulfate, 17-hydroxy-progesterone, sex hormone-binding globulin, and basal insulin and glucose levels were measured. Of the patients, 54% demonstrated an AE disorder (50%: polycystic ovary syndrome, 2%: hyperandrogenic insulin-resistant acanthosis nigricans syndrome, 2%: nonclassic adrenal hyperplasia), 29% isolated oligoovulation, 6% isolated hyperandrogenemia, and 10% had a normal evaluation. Of the patients with menstrual irregularities, 65% had an underlying AE disorder compared with 22% of those with normal menstrual function (P <. 001). Of eumenorrheic patients, 11% had oligo-ovulation and an AE disorder. Patients with minimal unwanted hair growth should be evaluated endocrinologically because approximately 50% of subjects demonstrate an AE disorder. Eumenorrhea does not preclude an underlying AE disorder, and ovulatory function should be assessed in these women.

Original languageEnglish (US)
Pages (from-to)1914-1920
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume191
Issue number6
DOIs
StatePublished - Dec 1 2004

Fingerprint

Hair
Androgens
Growth
Sex Hormone-Binding Globulin
Dehydroepiandrosterone Sulfate
Polycystic Ovary Syndrome
Ovulation
Progesterone
Testosterone
Insulin
Glucose

Keywords

  • Androgens
  • Hair growth
  • Hirsutism
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

The prevalence of androgen excess among patients with minimal unwanted hair growth. / Souter, Irene; Sanchez, Luis A.; Perez, Marilda; Bartolucci, Alfred A.; Azziz, Ricardo.

In: American Journal of Obstetrics and Gynecology, Vol. 191, No. 6, 01.12.2004, p. 1914-1920.

Research output: Contribution to journalArticle

Souter, Irene ; Sanchez, Luis A. ; Perez, Marilda ; Bartolucci, Alfred A. ; Azziz, Ricardo. / The prevalence of androgen excess among patients with minimal unwanted hair growth. In: American Journal of Obstetrics and Gynecology. 2004 ; Vol. 191, No. 6. pp. 1914-1920.
@article{e1d02b068c2c4d28a6b27bd461287850,
title = "The prevalence of androgen excess among patients with minimal unwanted hair growth",
abstract = "The prevalence of androgen excess (AE) and the value of preemptive endocrine evaluation in women with minimal unwanted hair growth are unclear. A total of 228 patients presented with minimal unwanted hair growth and a mF-G score of 5 or less. Total and free testosterone, dehydroepiandrosterone sulfate, 17-hydroxy-progesterone, sex hormone-binding globulin, and basal insulin and glucose levels were measured. Of the patients, 54{\%} demonstrated an AE disorder (50{\%}: polycystic ovary syndrome, 2{\%}: hyperandrogenic insulin-resistant acanthosis nigricans syndrome, 2{\%}: nonclassic adrenal hyperplasia), 29{\%} isolated oligoovulation, 6{\%} isolated hyperandrogenemia, and 10{\%} had a normal evaluation. Of the patients with menstrual irregularities, 65{\%} had an underlying AE disorder compared with 22{\%} of those with normal menstrual function (P <. 001). Of eumenorrheic patients, 11{\%} had oligo-ovulation and an AE disorder. Patients with minimal unwanted hair growth should be evaluated endocrinologically because approximately 50{\%} of subjects demonstrate an AE disorder. Eumenorrhea does not preclude an underlying AE disorder, and ovulatory function should be assessed in these women.",
keywords = "Androgens, Hair growth, Hirsutism, Polycystic ovary syndrome",
author = "Irene Souter and Sanchez, {Luis A.} and Marilda Perez and Bartolucci, {Alfred A.} and Ricardo Azziz",
year = "2004",
month = "12",
day = "1",
doi = "10.1016/j.ajog.2004.06.064",
language = "English (US)",
volume = "191",
pages = "1914--1920",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - The prevalence of androgen excess among patients with minimal unwanted hair growth

AU - Souter, Irene

AU - Sanchez, Luis A.

AU - Perez, Marilda

AU - Bartolucci, Alfred A.

AU - Azziz, Ricardo

PY - 2004/12/1

Y1 - 2004/12/1

N2 - The prevalence of androgen excess (AE) and the value of preemptive endocrine evaluation in women with minimal unwanted hair growth are unclear. A total of 228 patients presented with minimal unwanted hair growth and a mF-G score of 5 or less. Total and free testosterone, dehydroepiandrosterone sulfate, 17-hydroxy-progesterone, sex hormone-binding globulin, and basal insulin and glucose levels were measured. Of the patients, 54% demonstrated an AE disorder (50%: polycystic ovary syndrome, 2%: hyperandrogenic insulin-resistant acanthosis nigricans syndrome, 2%: nonclassic adrenal hyperplasia), 29% isolated oligoovulation, 6% isolated hyperandrogenemia, and 10% had a normal evaluation. Of the patients with menstrual irregularities, 65% had an underlying AE disorder compared with 22% of those with normal menstrual function (P <. 001). Of eumenorrheic patients, 11% had oligo-ovulation and an AE disorder. Patients with minimal unwanted hair growth should be evaluated endocrinologically because approximately 50% of subjects demonstrate an AE disorder. Eumenorrhea does not preclude an underlying AE disorder, and ovulatory function should be assessed in these women.

AB - The prevalence of androgen excess (AE) and the value of preemptive endocrine evaluation in women with minimal unwanted hair growth are unclear. A total of 228 patients presented with minimal unwanted hair growth and a mF-G score of 5 or less. Total and free testosterone, dehydroepiandrosterone sulfate, 17-hydroxy-progesterone, sex hormone-binding globulin, and basal insulin and glucose levels were measured. Of the patients, 54% demonstrated an AE disorder (50%: polycystic ovary syndrome, 2%: hyperandrogenic insulin-resistant acanthosis nigricans syndrome, 2%: nonclassic adrenal hyperplasia), 29% isolated oligoovulation, 6% isolated hyperandrogenemia, and 10% had a normal evaluation. Of the patients with menstrual irregularities, 65% had an underlying AE disorder compared with 22% of those with normal menstrual function (P <. 001). Of eumenorrheic patients, 11% had oligo-ovulation and an AE disorder. Patients with minimal unwanted hair growth should be evaluated endocrinologically because approximately 50% of subjects demonstrate an AE disorder. Eumenorrhea does not preclude an underlying AE disorder, and ovulatory function should be assessed in these women.

KW - Androgens

KW - Hair growth

KW - Hirsutism

KW - Polycystic ovary syndrome

UR - http://www.scopus.com/inward/record.url?scp=10044232633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10044232633&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2004.06.064

DO - 10.1016/j.ajog.2004.06.064

M3 - Article

VL - 191

SP - 1914

EP - 1920

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 6

ER -