@article{b8888e11d844464b8b0a2bdfffd16190,
title = "The rationale and design of the CPCRA (Terry Beirn Community Programs for Clinical Research on AIDS) 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) trial",
abstract = "The CPCRA (Terry Beirn Community Programs for Clinical Research on AIDS) 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) trial is a large, long-term, randomized, prospective comparison of three different antiretroviral strategies in highly active antiretroviral therapy-na{\"i}ve, HIV-1-infected persons. The trial was designed as a flexible framework upon which other studies could be added to answer more limited, but still important, questions. This article presents the study design, discusses the challenges we have faced in implementing the trial, and describes our preliminary experiences.",
keywords = "AIDS, Antiretroviral, Clinical trial design, Phase III study, Strategy",
author = "MacArthur, {Rodger David} and Li Chen and Mayers, {Douglas L.} and Besch, {C. Lynn} and Richard Novak and {Van Den Berg-Wolf}, Mary and Teresa Yurik and Grace Peng and Barry Schmetter and Barbara Brizz and Donald Abrams",
note = "Funding Information: This work is supported by CPCRA Grant No. AI42170-08 from the Division of AIDS, National Institute of Infectious Diseases, National Institutes of Health. The authors thank the research staff for their assistance in conducting this study and the patients for their participation in this research. Dr. James D. Neaton, editor of this journal, is the principle investigator of the Statistical and Data Management Center for the CPCRA.",
year = "2001",
doi = "10.1016/S0197-2456(01)00111-8",
language = "English (US)",
volume = "22",
pages = "176--190",
journal = "Controlled Clinical Trials",
issn = "0197-2456",
publisher = "Elsevier BV",
number = "2",
}
