Abstract
MicroRNAs (miRNA) are endogenous short noncoding RNAs, which regulate virtually all major cellular processes by inhibiting target gene expression. In kidneys, miRNAs have been implicated in renal development, homeostasis, and physiological functions. In addition, miRNAs play important roles in the pathogenesis of various renal diseases, including renal carcinoma, diabetic nephropathy, acute kidney injury, hypertensive nephropathy, polycystic kidney disease, and others. Furthermore, miRNAs may have great values as biomarkers in different kidney diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 602-615 |
| Number of pages | 14 |
| Journal | IUBMB Life |
| Volume | 65 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2013 |
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Keywords
- acute kidney injury
- allograft rejection
- biomarkers
- chronic kidney disease
- diabetic nephropathy
- hypertensive nephropathy
- kidney
- microRNA
- polycystic kidney disease
- renal cell carcinoma
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics
- Clinical Biochemistry
- Cell Biology
Cite this
The regulation and function of micrornas in kidney diseases. / Wei, QingQing; Mi, Qing Sheng; Dong, Zheng.
In: IUBMB Life, Vol. 65, No. 7, 01.07.2013, p. 602-615.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The regulation and function of micrornas in kidney diseases
AU - Wei, QingQing
AU - Mi, Qing Sheng
AU - Dong, Zheng
PY - 2013/7/1
Y1 - 2013/7/1
N2 - MicroRNAs (miRNA) are endogenous short noncoding RNAs, which regulate virtually all major cellular processes by inhibiting target gene expression. In kidneys, miRNAs have been implicated in renal development, homeostasis, and physiological functions. In addition, miRNAs play important roles in the pathogenesis of various renal diseases, including renal carcinoma, diabetic nephropathy, acute kidney injury, hypertensive nephropathy, polycystic kidney disease, and others. Furthermore, miRNAs may have great values as biomarkers in different kidney diseases.
AB - MicroRNAs (miRNA) are endogenous short noncoding RNAs, which regulate virtually all major cellular processes by inhibiting target gene expression. In kidneys, miRNAs have been implicated in renal development, homeostasis, and physiological functions. In addition, miRNAs play important roles in the pathogenesis of various renal diseases, including renal carcinoma, diabetic nephropathy, acute kidney injury, hypertensive nephropathy, polycystic kidney disease, and others. Furthermore, miRNAs may have great values as biomarkers in different kidney diseases.
KW - acute kidney injury
KW - allograft rejection
KW - biomarkers
KW - chronic kidney disease
KW - diabetic nephropathy
KW - hypertensive nephropathy
KW - kidney
KW - microRNA
KW - polycystic kidney disease
KW - renal cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84879381335&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879381335&partnerID=8YFLogxK
U2 - 10.1002/iub.1174
DO - 10.1002/iub.1174
M3 - Review article
C2 - 23794512
AN - SCOPUS:84879381335
VL - 65
SP - 602
EP - 615
JO - IUBMB Life
JF - IUBMB Life
SN - 1521-6543
IS - 7
ER -