The regulation and function of micrornas in kidney diseases

Qingqing Wei, Qing Sheng Mi, Zheng Dong

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

MicroRNAs (miRNA) are endogenous short noncoding RNAs, which regulate virtually all major cellular processes by inhibiting target gene expression. In kidneys, miRNAs have been implicated in renal development, homeostasis, and physiological functions. In addition, miRNAs play important roles in the pathogenesis of various renal diseases, including renal carcinoma, diabetic nephropathy, acute kidney injury, hypertensive nephropathy, polycystic kidney disease, and others. Furthermore, miRNAs may have great values as biomarkers in different kidney diseases.

Original languageEnglish (US)
Pages (from-to)602-614
Number of pages13
JournalIUBMB Life
Volume65
Issue number7
DOIs
StatePublished - Jul 2013

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Keywords

  • acute kidney injury
  • allograft rejection
  • biomarkers
  • chronic kidney disease
  • diabetic nephropathy
  • hypertensive nephropathy
  • kidney
  • microRNA
  • polycystic kidney disease
  • renal cell carcinoma

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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