TY - JOUR
T1 - The regulation of aldosterone secretion by leptin
T2 - Implications in obesity-related cardiovascular disease
AU - Faulkner, Jessica L.
AU - Bruder-Nascimento, Thiago
AU - Belin De Chantemèle, Eric J.
N1 - Publisher Copyright:
© 2018 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Purpose of review Although it has been known for some time that increases in body mass enhance aldosterone secretion, particularly in women, the origin of this elevation in aldosterone production is not well defined. Adipocyte-derived factors have emerged as potential candidates to increase aldosterone production in obesity. Recent findings Emerging evidence suggests the presence of a mechanistic link in which the adipocyte-derived hormone leptin stimulates aldosterone production in obesity, thereby creating a positive feedback loop for obesity-associated cardiovascular disease. In addition, recent reports give credence to the concept that this leptin-aldosterone stimulation pathway in obesity is an underlying mechanism for sex-discrepancies in obesity-associated cardiovascular disease. Summary Leptin appears as a new direct regulator of adrenal aldosterone production and leptin-mediated aldosterone production is a novel candidate mechanism underlying obesity-associated hypertension, particularly in females.
AB - Purpose of review Although it has been known for some time that increases in body mass enhance aldosterone secretion, particularly in women, the origin of this elevation in aldosterone production is not well defined. Adipocyte-derived factors have emerged as potential candidates to increase aldosterone production in obesity. Recent findings Emerging evidence suggests the presence of a mechanistic link in which the adipocyte-derived hormone leptin stimulates aldosterone production in obesity, thereby creating a positive feedback loop for obesity-associated cardiovascular disease. In addition, recent reports give credence to the concept that this leptin-aldosterone stimulation pathway in obesity is an underlying mechanism for sex-discrepancies in obesity-associated cardiovascular disease. Summary Leptin appears as a new direct regulator of adrenal aldosterone production and leptin-mediated aldosterone production is a novel candidate mechanism underlying obesity-associated hypertension, particularly in females.
KW - aldosterone
KW - hypertension
KW - leptin
KW - obesity
KW - sex differences
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U2 - 10.1097/MNH.0000000000000384
DO - 10.1097/MNH.0000000000000384
M3 - Review article
C2 - 29135585
AN - SCOPUS:85042419456
SN - 1062-4821
VL - 27
SP - 63
EP - 69
JO - Current opinion in nephrology and hypertension
JF - Current opinion in nephrology and hypertension
IS - 2
ER -