The regulatory mechanisms of export trafficking of G protein-coupled receptors

Matthew T. Duvernay, Catalin M. Filipeanu, Guangyu Wu

Research output: Contribution to journalReview article

114 Scopus citations

Abstract

G protein-coupled receptors (GPCRs) are a superfamily of cell-surface receptors that regulate a variety of cell functions by responding to a myriad of ligands. The magnitude of the response elicited by a ligand is dictated by the level of receptor available at the plasma membrane. GPCR expression levels at the cell surface are a balance of three highly regulated, dynamic intracellular trafficking processes, namely export, internalization and degradation. This review will cover recent advances in understanding the mechanism underlying GPCR export trafficking by focusing on specific motifs required for ER export and the role of the Ras-like Rab1 GTPase and glycosylation in regulating ER-Golgi-cell-surface transport. The manifestation of diseases due to the disruption of GPCR export is also discussed.

Original languageEnglish (US)
Pages (from-to)1457-1465
Number of pages9
JournalCellular Signalling
Volume17
Issue number12
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

Keywords

  • ER-export motif
  • Export trafficking
  • G protein-coupled receptor
  • Glycosylation
  • Rab GTPase
  • Signal transduction

ASJC Scopus subject areas

  • Cell Biology

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