The relationship of angiogenesis to biological activity in human squamous cell carcinomas of the head and neck

Daniel Albo, M. S. Granick, N. Jhala, B. Atkinson, M. P. Solomon

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Tumor angiogenesis has recently been related to tumor growth and metastasis, which determine the clinical outcome of the patient. This study was designed to determine the relationship between angiogenesis in primary squamous cell carcinomas (SCC) of the head and neck and the development of recurrent or metastatic disease, or both. Different SCC of the head and neck were studied. Microvessels were selectively stained using a monoclonal antibody for factor VIII. Microvessel counts were performed in the tumor, in the tissues immediately adjacent, and in normal tissues of similar topographies. Microvessel counts were then correlated with clinical outcome (development of recurrent or metastatic disease, or both). Recurrent or metastatic disease, or both, developed in patients with high microvessel counts (mean, 121.25) in the tissues adjacent to the tumor 7 to 16 months after initial treatment. Those with low microvessel counts (mean, 33.75) were disease-free for 16 months to 6 years (p < 0.01). Microvessel counts inside the tumor were also higher in those in whom recurrences or metastasis, or both, developed, but were not statistically significant. In this study, angiogenesis was directly related to clinical outcome. Thus, angiogenesis may be an independent predictor of recurrent or metastatic disease, or both, which could help in the selection of patients with SCC of the head and neck for aggressive therapy.

Original languageEnglish (US)
Pages (from-to)588-594
Number of pages7
JournalAnnals of Plastic Surgery
Volume32
Issue number6
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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Microvessels
Human Activities
Neoplasms
Neoplasm Metastasis
Factor VIII
Patient Selection
Carcinoma, squamous cell of head and neck
Monoclonal Antibodies
Recurrence
Therapeutics
Growth

ASJC Scopus subject areas

  • Surgery

Cite this

The relationship of angiogenesis to biological activity in human squamous cell carcinomas of the head and neck. / Albo, Daniel; Granick, M. S.; Jhala, N.; Atkinson, B.; Solomon, M. P.

In: Annals of Plastic Surgery, Vol. 32, No. 6, 01.01.1994, p. 588-594.

Research output: Contribution to journalArticle

Albo, Daniel ; Granick, M. S. ; Jhala, N. ; Atkinson, B. ; Solomon, M. P. / The relationship of angiogenesis to biological activity in human squamous cell carcinomas of the head and neck. In: Annals of Plastic Surgery. 1994 ; Vol. 32, No. 6. pp. 588-594.
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