The relationship of minor physical anomalies and other putative indices of developmental disturbance in schizophrenia to abnormalities of cerebral structure on magnetic resonance imaging

Eadbhard O'Callaghan, Peter Buckley, Cathy Madigan, Oonagh Redmond, John P. Stack, Anthony Kinsella, Conall Larkin, Joseph T. Ennis, John L. Waddington

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Minor physical anomalies, together with obstetric complications, family history, and handedness status, were assessed to explore putative neurodevelopmental disturbance(s) in patients with schizophrenia whose cerebral structure had been examined previously by magnetic resonance imaging. Minor physical anomalies were related to negative symptoms in males and to premorbid intellectual function in females, but not to ventricular volume; however, three patients with evident neurodevelopmental anomalies of the ventricular system showed prominent minor physical anomalies. In exploratory analyses, obstetric complications were associated with left ventricular asymmetry, and a positive family history with inverse profiles of asymmetry in males vs. females; non-right-handedness was associated with increased ventricular volume in males but with poorer premorbid intellectual function in females. This nexus of relationships and their gender specificities suggest early dysmorphogenesis in schizophrenia that is related to sexual dimorphism.

Original languageEnglish (US)
Pages (from-to)516-524
Number of pages9
JournalBiological Psychiatry
Volume38
Issue number8
DOIs
StatePublished - Oct 15 1995

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Schizophrenia
Functional Laterality
Magnetic Resonance Imaging
Obstetrics
Sex Characteristics
Nexus

Keywords

  • gender differences
  • magnetic resonance imaging
  • minor physical anomalies
  • neurodevelopment
  • Schizophrenia
  • sexual dimorphism

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

The relationship of minor physical anomalies and other putative indices of developmental disturbance in schizophrenia to abnormalities of cerebral structure on magnetic resonance imaging. / O'Callaghan, Eadbhard; Buckley, Peter; Madigan, Cathy; Redmond, Oonagh; Stack, John P.; Kinsella, Anthony; Larkin, Conall; Ennis, Joseph T.; Waddington, John L.

In: Biological Psychiatry, Vol. 38, No. 8, 15.10.1995, p. 516-524.

Research output: Contribution to journalArticle

O'Callaghan, Eadbhard ; Buckley, Peter ; Madigan, Cathy ; Redmond, Oonagh ; Stack, John P. ; Kinsella, Anthony ; Larkin, Conall ; Ennis, Joseph T. ; Waddington, John L. / The relationship of minor physical anomalies and other putative indices of developmental disturbance in schizophrenia to abnormalities of cerebral structure on magnetic resonance imaging. In: Biological Psychiatry. 1995 ; Vol. 38, No. 8. pp. 516-524.
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