The relevance of antigen binding to the pathogenicity of lupus autoantibodies

Michael P. Madaio

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Abstract

Although lupus autoantibodies provide diagnostic value, discordance between serum levels and nephritis poses mechanistic questions. Krishnan and co-workers report that only those that crossreact with basement membrane components produce immune deposits. Thus, other glomerular binding properties probably define where deposits form. Thereafter, Fc-and complement-mediated events influence disease expression. Clearly other factors determine the ultimate phenotype; however, the findings provide insights into the variable disease patterns in lupus nephritis.

Original languageEnglish (US)
Pages (from-to)125-127
Number of pages3
JournalKidney International
Volume82
Issue number2
DOIs
StatePublished - Jul 2 2012

Fingerprint

Autoantibodies
Virulence
Antigens
Lupus Nephritis
Nephritis
Basement Membrane
Phenotype
Serum

ASJC Scopus subject areas

  • Nephrology

Cite this

The relevance of antigen binding to the pathogenicity of lupus autoantibodies. / Madaio, Michael P.

In: Kidney International, Vol. 82, No. 2, 02.07.2012, p. 125-127.

Research output: Contribution to journalComment/debate

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