The relevance of antigen binding to the pathogenicity of lupus autoantibodies

Michael P. Madaio

Research output: Contribution to journalComment/debatepeer-review

7 Scopus citations


Although lupus autoantibodies provide diagnostic value, discordance between serum levels and nephritis poses mechanistic questions. Krishnan and co-workers report that only those that crossreact with basement membrane components produce immune deposits. Thus, other glomerular binding properties probably define where deposits form. Thereafter, Fc-and complement-mediated events influence disease expression. Clearly other factors determine the ultimate phenotype; however, the findings provide insights into the variable disease patterns in lupus nephritis.

Original languageEnglish (US)
Pages (from-to)125-127
Number of pages3
JournalKidney International
Issue number2
StatePublished - Jul 2 2012
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology


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