The role of antibodies and B cells in the pathogenesis of lupus nephritis

Mark J. Shlomchik, Michael P. Madaio

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

Nephritis occurs commonly in lupus patients, and many immunological and nonimmunological factors contribute to disease expression. It is generally appreciated that glomerular immune deposit formation is an early and initiating event, although the mechanisms leading to the deposition of nephritogenic antibodies continue to be debated. Furthermore, it has recently become evident that autoantibodies expressed on B cells also play an important role in pathogenesis. This review focuses on the properties of nephritogenic autoantibodies, their mechanisms of immune deposit formation, and the contribution of B cells expressing autoantibodies to lupus nephritis.

Original languageEnglish (US)
Pages (from-to)363-375
Number of pages13
JournalSpringer Seminars in Immunopathology
Volume24
Issue number4
DOIs
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Immunology

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