The role of B cells in lpr/lpr-induced autoimmunity

Mark J. Shlomchik, Michael P. Madaio, Donghui Ni, Mary Trounstein, Dennis Huszar

Research output: Contribution to journalArticle

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Abstract

The primary roles of T cells and B cells in the initiation of systemic autoimmunity are unclear. To investigate the role of B cells, we crossed the 'Jh knockout' mutation onto the autoimmune lpr/lpr background. Animals homozygous for both traits were obtained. As expected, these animals lack B cells. These animals also show no signs of autoimmune kidney destruction nor vasculitis, in spite of carrying the lpr/lpr mutation. In contrast, lpr/lpr littermates that had B cells had severe nephritis and vasculitis, as well as autoantibodies. These results demonstrate a primary role for B cells and/or (auto)antibodies in initiating several types of autoimmune-mediated tissue destruction. The implications of this finding for models and therapy of autoimmunity are discussed.

Original languageEnglish (US)
Pages (from-to)1295-1306
Number of pages12
JournalJournal of Experimental Medicine
Volume180
Issue number4
DOIs
StatePublished - Oct 1 1994

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Autoimmunity
B-Lymphocytes
Vasculitis
Mutation
Nephritis
Autoantibodies
T-Lymphocytes
Kidney
Antibodies
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Shlomchik, M. J., Madaio, M. P., Ni, D., Trounstein, M., & Huszar, D. (1994). The role of B cells in lpr/lpr-induced autoimmunity. Journal of Experimental Medicine, 180(4), 1295-1306. https://doi.org/10.1084/jem.180.4.1295

The role of B cells in lpr/lpr-induced autoimmunity. / Shlomchik, Mark J.; Madaio, Michael P.; Ni, Donghui; Trounstein, Mary; Huszar, Dennis.

In: Journal of Experimental Medicine, Vol. 180, No. 4, 01.10.1994, p. 1295-1306.

Research output: Contribution to journalArticle

Shlomchik, MJ, Madaio, MP, Ni, D, Trounstein, M & Huszar, D 1994, 'The role of B cells in lpr/lpr-induced autoimmunity', Journal of Experimental Medicine, vol. 180, no. 4, pp. 1295-1306. https://doi.org/10.1084/jem.180.4.1295
Shlomchik MJ, Madaio MP, Ni D, Trounstein M, Huszar D. The role of B cells in lpr/lpr-induced autoimmunity. Journal of Experimental Medicine. 1994 Oct 1;180(4):1295-1306. https://doi.org/10.1084/jem.180.4.1295
Shlomchik, Mark J. ; Madaio, Michael P. ; Ni, Donghui ; Trounstein, Mary ; Huszar, Dennis. / The role of B cells in lpr/lpr-induced autoimmunity. In: Journal of Experimental Medicine. 1994 ; Vol. 180, No. 4. pp. 1295-1306.
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