The role of brain single photon emission computed tomography in the diagnosis of primary progressive aphasia

Keith D. Mcdaniel; Mark T. Wagner; Bennett S. Greenspan

doi:10.1001/archneur.1991.00530240061021

The role of brain single photon emission computed tomography in the diagnosis of primary progressive aphasia

Keith D. Mcdaniel, Mark T. Wagner, Bennett S. Greenspan

Radiology and Imaging

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

We present two cases of primary progressive aphasia studied with neuropsychologic measures, computed tomography or magnetic resonance imaging, and single-photon emission computed tomography with technetium Tc 99m-labeled hexamethyl-propyleneamine oxime. Clinical and neuropsychologic observations revealed a marked, progressive loss of language functions over time with relative preservation of nonlanguage cognitive functions in both patients. The brain single-photon emission computed tomographic scan revealed marked left frontal and minimal left temporal and parietal hypoperfusion in case 1 and marked left posterior frontal and minimal left temporal hypoperfusion in case 2. The value of brain single-photon emission computed tomography in distinguishing primary progressive aphasia from Alzheimer's disease is described.

Original language	English (US)
Pages (from-to)	1257-1260
Number of pages	4
Journal	Archives of Neurology
Volume	48
Issue number	12
DOIs	https://doi.org/10.1001/archneur.1991.00530240061021
State	Published - Dec 1991

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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AB - We present two cases of primary progressive aphasia studied with neuropsychologic measures, computed tomography or magnetic resonance imaging, and single-photon emission computed tomography with technetium Tc 99m-labeled hexamethyl-propyleneamine oxime. Clinical and neuropsychologic observations revealed a marked, progressive loss of language functions over time with relative preservation of nonlanguage cognitive functions in both patients. The brain single-photon emission computed tomographic scan revealed marked left frontal and minimal left temporal and parietal hypoperfusion in case 1 and marked left posterior frontal and minimal left temporal hypoperfusion in case 2. The value of brain single-photon emission computed tomography in distinguishing primary progressive aphasia from Alzheimer's disease is described.

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The role of brain single photon emission computed tomography in the diagnosis of primary progressive aphasia

Abstract

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