The role of brain single photon emission computed tomography in the diagnosis of primary progressive aphasia

Keith D. Mcdaniel, Mark T. Wagner, Bennett S. Greenspan

Research output: Contribution to journalArticle

37 Scopus citations


We present two cases of primary progressive aphasia studied with neuropsychologic measures, computed tomography or magnetic resonance imaging, and single-photon emission computed tomography with technetium Tc 99m-labeled hexamethyl-propyleneamine oxime. Clinical and neuropsychologic observations revealed a marked, progressive loss of language functions over time with relative preservation of nonlanguage cognitive functions in both patients. The brain single-photon emission computed tomographic scan revealed marked left frontal and minimal left temporal and parietal hypoperfusion in case 1 and marked left posterior frontal and minimal left temporal hypoperfusion in case 2. The value of brain single-photon emission computed tomography in distinguishing primary progressive aphasia from Alzheimer's disease is described.

Original languageEnglish (US)
Pages (from-to)1257-1260
Number of pages4
JournalArchives of Neurology
Issue number12
StatePublished - Dec 1991


ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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