The role of cytoskeleton in the regulation of vascular endothelial barrier function

Natalia V. Bogatcheva, Alexander D. Verin

Research output: Contribution to journalReview article

120 Scopus citations

Abstract

The cytoskeleton is vital to the function of virtually all cell types in the organism as it is required for cell division, cell motility, endo- or exocytosis and the maintenance of cell shape. Endothelial cells, lining the inner surface of the blood vessels, exploit cytoskeletal elements to ensure the integrity of cell monolayer in quiescent endothelium, and to enable the disintegration of the formed barrier in response to various agonists. Vascular permeability is defined by the combination of transcellular and paracellular pathways, with the latter being a major contributor to the inflammation-induced barrier dysfunction. This review will analyze the cytoskeletal elements, which reorganization affects endothelial permeability, and emphasize signaling mechanisms with barrier-protective or barrier-disruptive potential.

Original languageEnglish (US)
Pages (from-to)202-207
Number of pages6
JournalMicrovascular Research
Volume76
Issue number3
DOIs
StatePublished - Nov 1 2008

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Keywords

  • Barrier function
  • Cytoskeleton
  • Endothelial
  • Permeability

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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