The role of endoplasmic reticulum (ER) stress in mediating the apoptotic effect of selenium compounds

Hidemi Rikiishi, Maiko Suzuki

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Converging data from epidemiological, ecological, and clinical studies have shown that selenium (Se) can decrease the risk for some types of human cancers. Mechanisms of the anti-cancer action of Se compounds are not fully understood; however, several have been proposed, which include the induction of cell apoptosis, inhibition of cell proliferation, modulation of the redox state, detoxification of carcinogen, stimulation of the immune system, and inhibition of angiogenesis. Among these potential mechanisms of Se action, the induction of apoptosis is considered an important cellular event that can account for the cancer preventive eff ects of Se. Prior to the occurrence of apoptosis, the accumulation of aberrantly folded proteins in the endoplasmic reticulum (ER) triggers a defined set of transducers to correct the defects or commit the cells to apoptosis if the rescue eff ort is exhausted. Se compounds alter the expression and/or activities of ER stress-associated and mitochondria-associated signaling molecules. Mechanistic studies have demonstrated that the methylselenol metabolite pool has many desirable attributes of chemoprevention, whereas the hydrogen selenide pool with excess selenoprotein synthesis can lead to DNA single-strand breaks. This ambiguity is due to several factors, including the chemical nature of Se compounds (inorganic vs. organic) and their intracellular metabolism, the type of experimental model, and the dose used. This chapter focuses on elucidation of the molecular mechanisms of cancer prevention by Se with the apoptotic events via the ER stress response.

Original languageEnglish (US)
Title of host publicationApoptosis
Subtitle of host publicationModern Insights into Disease from Molecules to Man
PublisherCRC Press
Pages97-111
Number of pages15
ISBN (Electronic)9781439845431
ISBN (Print)9781578085835
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rikiishi, H., & Suzuki, M. (2010). The role of endoplasmic reticulum (ER) stress in mediating the apoptotic effect of selenium compounds. In Apoptosis: Modern Insights into Disease from Molecules to Man (pp. 97-111). CRC Press. https://doi.org/10.1201/9781439845431