The role of sigma 1 receptor as a neuroprotective target in glaucoma

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The role of sigma 1 receptor (S1R) in glaucoma is emerging as a promising field of study. Glaucoma is an optic neuropathy that shares common pathogenic mechanisms with other neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. S1R modulates multiple cellular functions associated with neurodegeneration. These include Ca2+ ion homeostasis, endoplasmic reticulum (ER) and oxidative stress, survival signaling pathways, neurotrophin secretion, and glial activation. S1R may also have neurorestorative properties including enhancement of neuronal plasticity and neurite outgrowth. Recent studies using agonists for S1R within the eye provide hope that it could be a therapeutic target for glaucoma. Understanding the role of S1R in glaucoma may help us to stop the progression of this sight threatening disease.

Original languageEnglish (US)
Pages (from-to)299-307
Number of pages9
JournalAdvances in experimental medicine and biology
Volume964
DOIs
StatePublished - Jan 1 2017

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Glaucoma
Neurodegenerative diseases
Optic Nerve Diseases
Endoplasmic Reticulum Stress
Neuronal Plasticity
Oxidative stress
Secretory Pathway
Nerve Growth Factors
Neuroglia
Neurodegenerative Diseases
Plasticity
Parkinson Disease
Optics
Alzheimer Disease
Oxidative Stress
Homeostasis
Chemical activation
sigma-1 receptor
Ions
Neuronal Outgrowth

Keywords

  • Glaucoma
  • Neurodegeneration
  • Neuroprotection
  • Optic nerve
  • Retinal ganglion cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The role of sigma 1 receptor as a neuroprotective target in glaucoma. / Mysona, Barbara A; Kansara, Neil; Zhao, Jing; Bollinger, Kathryn Elizabeth.

In: Advances in experimental medicine and biology, Vol. 964, 01.01.2017, p. 299-307.

Research output: Contribution to journalArticle

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