The role of sigma 1 receptor as a neuroprotective target in glaucoma

Barbara Mysona; Neil Kansara; Jing Zhao; Kathryn Bollinger

doi:10.1007/978-3-319-50174-1_20

The role of sigma 1 receptor as a neuroprotective target in glaucoma

Barbara Mysona, Neil Kansara, Jing Zhao, Kathryn Bollinger

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The role of sigma 1 receptor (S1R) in glaucoma is emerging as a promising field of study. Glaucoma is an optic neuropathy that shares common pathogenic mechanisms with other neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. S1R modulates multiple cellular functions associated with neurodegeneration. These include Ca2+ ion homeostasis, endoplasmic reticulum (ER) and oxidative stress, survival signaling pathways, neurotrophin secretion, and glial activation. S1R may also have neurorestorative properties including enhancement of neuronal plasticity and neurite outgrowth. Recent studies using agonists for S1R within the eye provide hope that it could be a therapeutic target for glaucoma. Understanding the role of S1R in glaucoma may help us to stop the progression of this sight threatening disease.

Original language	English (US)
Pages (from-to)	299-307
Number of pages	9
Journal	Advances in experimental medicine and biology
Volume	964
DOIs	https://doi.org/10.1007/978-3-319-50174-1_20
State	Published - 2017

Keywords

Glaucoma
Neurodegeneration
Neuroprotection
Optic nerve
Retinal ganglion cell

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-3-319-50174-1_20

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title = "The role of sigma 1 receptor as a neuroprotective target in glaucoma",

abstract = "The role of sigma 1 receptor (S1R) in glaucoma is emerging as a promising field of study. Glaucoma is an optic neuropathy that shares common pathogenic mechanisms with other neurodegenerative diseases such as Alzheimer{\textquoteright}s and Parkinson{\textquoteright}s disease. S1R modulates multiple cellular functions associated with neurodegeneration. These include Ca2+ ion homeostasis, endoplasmic reticulum (ER) and oxidative stress, survival signaling pathways, neurotrophin secretion, and glial activation. S1R may also have neurorestorative properties including enhancement of neuronal plasticity and neurite outgrowth. Recent studies using agonists for S1R within the eye provide hope that it could be a therapeutic target for glaucoma. Understanding the role of S1R in glaucoma may help us to stop the progression of this sight threatening disease.",

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AU - Kansara, Neil

AU - Zhao, Jing

AU - Bollinger, Kathryn

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PY - 2017

Y1 - 2017

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AB - The role of sigma 1 receptor (S1R) in glaucoma is emerging as a promising field of study. Glaucoma is an optic neuropathy that shares common pathogenic mechanisms with other neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. S1R modulates multiple cellular functions associated with neurodegeneration. These include Ca2+ ion homeostasis, endoplasmic reticulum (ER) and oxidative stress, survival signaling pathways, neurotrophin secretion, and glial activation. S1R may also have neurorestorative properties including enhancement of neuronal plasticity and neurite outgrowth. Recent studies using agonists for S1R within the eye provide hope that it could be a therapeutic target for glaucoma. Understanding the role of S1R in glaucoma may help us to stop the progression of this sight threatening disease.

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KW - Neurodegeneration

KW - Neuroprotection

KW - Optic nerve

KW - Retinal ganglion cell

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The role of sigma 1 receptor as a neuroprotective target in glaucoma

Abstract

Keywords

ASJC Scopus subject areas

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