The role of the adrenal cortex in polycystic ovary syndrome

C. Moran, R. Azziz

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Adrenal androgen excess affects approximately 25% of PCOS patients. The exact etiology of this excess in PCOS patients is unclear. Some evidence that adrenal androgen excess may be a genetic trait. The adrenal androgen response to ACTH is highly individualized, and the relative response seems to be constant over time. In addition, there is a strong familial component to adrenal androgen levels in normal individuals and PCOS patients. It is possible that the tendency to overproduce adrenal androgens is an inherited risk factor for the development of PCOS. Overall, few hyperandrogenic patients actually have isolated deficiencies of 3β-hydroxysteroid dehydrogenase, 21-hydroxylase, and 11-hydroxylase. The ovarian hormonal secretion in PCOS can affect adrenal androgen secretion and metabolism, although this factor accounts for only part of this abnormality. More likely, the adrenal androgen excess results from a generalized hyperresponsiveness of the adrenal cortex to ACTH, but without an increase in CRH or ACTH sensitivity. Although glucocorticoid administration may improve the ovulatory function of these patients, the results are modest and cannot be predicted by the circulating androgen levels.

Original languageEnglish (US)
Pages (from-to)63-75
Number of pages13
JournalObstetrics and Gynecology Clinics of North America
Volume28
Issue number1
DOIs
StatePublished - Mar 7 2001

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Polycystic Ovary Syndrome
Adrenal Cortex
Androgens
Adrenocorticotropic Hormone
3-Hydroxysteroid Dehydrogenases
Steroid 21-Hydroxylase
Mixed Function Oxygenases
Glucocorticoids

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

The role of the adrenal cortex in polycystic ovary syndrome. / Moran, C.; Azziz, R.

In: Obstetrics and Gynecology Clinics of North America, Vol. 28, No. 1, 07.03.2001, p. 63-75.

Research output: Contribution to journalArticle

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