The role of tumor suppressor short non-coding RNAs on breast cancer

Shokooh Salimimoghadam, Sina Taefehshokr, Reid Loveless, Yong Teng, Gloria Bertoli, Nima Taefehshokr, Fatemeh Musaviaroo, Khalil Hajiasgharzadeh, Behzad Baradaran

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Characterized by remarkable levels of aggression and malignancy, BC remains one of the leading causes of death in females world wide. Accordingly, significant efforts have been made to develop early diagnostic tools, increase treatment efficacy, and improve patient prognosis. Hopefully, many of the molecular mechanisms underlying BC have been detected and show promising targeting potential. In particular, short and long non-coding RNAs (ncRNAs) are a class of endogenous BC controllers and include a number of different species including microRNAs, Piwi-interacting RNAs, small nucleolar RNA, short interfering RNAs, and tRNA-derivatives. In this review, we discuss the tumor suppressing roles of ncRNAs in the context of BC, and the mechanisms by which ncRNAs target tumor hallmarks, including apoptosis, proliferation, invasion, metastasis, epithelial-mesenchymal transition, angiogenesis, and cell cycle progression, in addition to their diagnostic and prognostic significance in cancer treatment.

Original languageEnglish (US)
Article number103210
JournalCritical Reviews in Oncology/Hematology
Volume158
DOIs
StatePublished - Feb 2021

Keywords

  • Apoptosis
  • BC
  • Metastasis
  • Small non-coding RNA
  • miRNA
  • piRNA
  • siRNA
  • snoRNA

ASJC Scopus subject areas

  • Hematology
  • Oncology

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