The role of typical and atypical antipsychotic medications in the management of agitation and aggression

Peter F Buckley

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The management of agitation and aggression in psychiatric inpatients is a significant clinical dilemma. Establishing a clear diagnosis and distinguishing whether aggression is an acute manifestation or a longstanding or repetitive problem are fundamental antecedents of medication treatment. For acute aggression, either benzodiazepines or antipsychotic medications (typical and atypical) are recommended choices. Currently, on the basis of efficacy, ease of use, and availability in multiple (tablet, liquid, intramuscular) preparations, typical antipsychotics such as loxapine should be considered as first choice for acute aggression (in psychosis). On the other hand, atypical antipsychotics, particularly clozapine, should be considered when aggression in psychosis persists and/or is repetitive. Typical antipsychotics are indicated for persistent aggression in psychosis when medication noncompliance is the obstacle to effective treatment.

Original languageEnglish (US)
Pages (from-to)52-60
Number of pages9
JournalJournal of Clinical Psychiatry
Volume60
Issue numberSUPPL. 10
StatePublished - May 31 1999

Fingerprint

Aggression
Antipsychotic Agents
Psychotic Disorders
Loxapine
Medication Adherence
Clozapine
Benzodiazepines
Tablets
Psychiatry
Inpatients
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

The role of typical and atypical antipsychotic medications in the management of agitation and aggression. / Buckley, Peter F.

In: Journal of Clinical Psychiatry, Vol. 60, No. SUPPL. 10, 31.05.1999, p. 52-60.

Research output: Contribution to journalArticle

@article{b2d3a8c541764a0ebeb65d5a4dccce07,
title = "The role of typical and atypical antipsychotic medications in the management of agitation and aggression",
abstract = "The management of agitation and aggression in psychiatric inpatients is a significant clinical dilemma. Establishing a clear diagnosis and distinguishing whether aggression is an acute manifestation or a longstanding or repetitive problem are fundamental antecedents of medication treatment. For acute aggression, either benzodiazepines or antipsychotic medications (typical and atypical) are recommended choices. Currently, on the basis of efficacy, ease of use, and availability in multiple (tablet, liquid, intramuscular) preparations, typical antipsychotics such as loxapine should be considered as first choice for acute aggression (in psychosis). On the other hand, atypical antipsychotics, particularly clozapine, should be considered when aggression in psychosis persists and/or is repetitive. Typical antipsychotics are indicated for persistent aggression in psychosis when medication noncompliance is the obstacle to effective treatment.",
author = "Buckley, {Peter F}",
year = "1999",
month = "5",
day = "31",
language = "English (US)",
volume = "60",
pages = "52--60",
journal = "Journal of Clinical Psychiatry",
issn = "0160-6689",
publisher = "Physicians Postgraduate Press Inc.",
number = "SUPPL. 10",

}

TY - JOUR

T1 - The role of typical and atypical antipsychotic medications in the management of agitation and aggression

AU - Buckley, Peter F

PY - 1999/5/31

Y1 - 1999/5/31

N2 - The management of agitation and aggression in psychiatric inpatients is a significant clinical dilemma. Establishing a clear diagnosis and distinguishing whether aggression is an acute manifestation or a longstanding or repetitive problem are fundamental antecedents of medication treatment. For acute aggression, either benzodiazepines or antipsychotic medications (typical and atypical) are recommended choices. Currently, on the basis of efficacy, ease of use, and availability in multiple (tablet, liquid, intramuscular) preparations, typical antipsychotics such as loxapine should be considered as first choice for acute aggression (in psychosis). On the other hand, atypical antipsychotics, particularly clozapine, should be considered when aggression in psychosis persists and/or is repetitive. Typical antipsychotics are indicated for persistent aggression in psychosis when medication noncompliance is the obstacle to effective treatment.

AB - The management of agitation and aggression in psychiatric inpatients is a significant clinical dilemma. Establishing a clear diagnosis and distinguishing whether aggression is an acute manifestation or a longstanding or repetitive problem are fundamental antecedents of medication treatment. For acute aggression, either benzodiazepines or antipsychotic medications (typical and atypical) are recommended choices. Currently, on the basis of efficacy, ease of use, and availability in multiple (tablet, liquid, intramuscular) preparations, typical antipsychotics such as loxapine should be considered as first choice for acute aggression (in psychosis). On the other hand, atypical antipsychotics, particularly clozapine, should be considered when aggression in psychosis persists and/or is repetitive. Typical antipsychotics are indicated for persistent aggression in psychosis when medication noncompliance is the obstacle to effective treatment.

UR - http://www.scopus.com/inward/record.url?scp=0032961509&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032961509&partnerID=8YFLogxK

M3 - Article

C2 - 10340688

AN - SCOPUS:0032961509

VL - 60

SP - 52

EP - 60

JO - Journal of Clinical Psychiatry

JF - Journal of Clinical Psychiatry

SN - 0160-6689

IS - SUPPL. 10

ER -