The role of uridine adenosine tetraphosphate in the vascular system

Takayuki Matsumoto, Rita C. Tostes, R Clinton Webb

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.

Original languageEnglish (US)
Article number435132
JournalAdvances in Pharmacological Sciences
Volume2011
DOIs
StatePublished - Dec 1 2011

Fingerprint

Blood Vessels
Endothelium
Cardiovascular Diseases
Purinergic Receptors
Smooth Muscle Myocytes
uridine adenosine tetraphosphate
Atherosclerosis
Homeostasis
Hypertension

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

The role of uridine adenosine tetraphosphate in the vascular system. / Matsumoto, Takayuki; Tostes, Rita C.; Webb, R Clinton.

In: Advances in Pharmacological Sciences, Vol. 2011, 435132, 01.12.2011.

Research output: Contribution to journalArticle

@article{9fadf7f7f1474dc88af3b8ff98bac5f6,
title = "The role of uridine adenosine tetraphosphate in the vascular system",
abstract = "The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.",
author = "Takayuki Matsumoto and Tostes, {Rita C.} and Webb, {R Clinton}",
year = "2011",
month = "12",
day = "1",
doi = "10.1155/2011/435132",
language = "English (US)",
volume = "2011",
journal = "Advances in Pharmacological Sciences",
issn = "1687-6334",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - The role of uridine adenosine tetraphosphate in the vascular system

AU - Matsumoto, Takayuki

AU - Tostes, Rita C.

AU - Webb, R Clinton

PY - 2011/12/1

Y1 - 2011/12/1

N2 - The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.

AB - The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.

UR - http://www.scopus.com/inward/record.url?scp=84555196361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84555196361&partnerID=8YFLogxK

U2 - 10.1155/2011/435132

DO - 10.1155/2011/435132

M3 - Article

C2 - 22110488

AN - SCOPUS:84555196361

VL - 2011

JO - Advances in Pharmacological Sciences

JF - Advances in Pharmacological Sciences

SN - 1687-6334

M1 - 435132

ER -