The safety of Bosutinib for the treatment of chronic myeloid leukemia

Jee Hyun Kong, H. Khoury, Audrey Sunwha Kim, Brittany Gray Hill, Vamsi Kota

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Introduction: Tyrosine kinase inhibitors (TKIs) are a potentially lifelong treatment for patients with chronic myeloid leukemia (CML). Adverse events (AEs) associated with TKIs are significant impediments in the daily life of patients that can impact compliance, and efficacy. Areas covered: This is a review on safety of bosutinib in the treatment of chronic phase CML. Data is extracted from the latest updates of bosutinib phase I/II and III trials. Expert opinion: Bosutinib is an effective agent against all phases of CML presently approved for the treatment in patients with resistance or intolerance to prior TKI therapy. Bosutinib has a unique toxicity profile characterized by early and transient diarrhea. Otherwise, the AE profile of bosutinib is comparable to other TKIs, with the exception of cardiovascular AEs that are infrequent in bosutinib-treated patients. Similar to other TKIs, the minimum effective dose of bosutinib remains unknown. Better definition of the optimal effective dose may spare, for those patients otherwise benefitting from treatment, unnecessary AEs.

Original languageEnglish (US)
Pages (from-to)1203-1209
Number of pages7
JournalExpert Opinion on Drug Safety
Volume16
Issue number10
DOIs
StatePublished - Oct 3 2017

Keywords

  • Bosutinib
  • chronic myeloid leukemia
  • efficacy
  • safety

ASJC Scopus subject areas

  • Pharmacology (medical)

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