TY - JOUR
T1 - The spectrum of lymphoblastic, nodal and extranodal T-cell lymphomas
T2 - Characteristic features and diagnostic dilemmas
AU - Savage, Natasha M.
AU - Johnson, Ryan C.
AU - Natkunam, Yasodha
PY - 2013/4
Y1 - 2013/4
N2 - T-cell lymphomas represent a heterogeneous group of neoplasms that encompass considerable clinical, morphologic, and immunophenotypic variation. The diagnosis of T-cell lymphoma is challenging because of its relative rarity, the lack of an immunophenotypic marker of clonality, and significant morphologic overlap with infectious/inflammatory processes and neoplasms, including Hodgkin and other non-Hodgkin lymphomas, and even mesenchymal or epithelial lesions. In the current World Health Organization classification of hematopoietic tumors, all except 1 subtype (ie, T-lymphoblastic lymphoma) are recognized as mature neoplasms derived from postthymic T cells. In addition to T-lymphoblastic lymphoma, this review will focus on nodal and extranodal T-cell lymphomas and exclude T-cell lymphomas presenting primarily in the skin. Extranodal natural-killer-cell/T-cell lymphoma, nasal type, will also be discussed because the derivation of this lymphoma from natural killer and natural killer-like T cells shows morphologic and immunophenotypic features that overlap with other T-cell lymphomas. In this review, we discuss the salient clinicopathologic, immunophenotypic, and genetic features, as well as our approaches to the diagnosis of lymphoblastic, nodal, and extranodal T-cell lymphomas.
AB - T-cell lymphomas represent a heterogeneous group of neoplasms that encompass considerable clinical, morphologic, and immunophenotypic variation. The diagnosis of T-cell lymphoma is challenging because of its relative rarity, the lack of an immunophenotypic marker of clonality, and significant morphologic overlap with infectious/inflammatory processes and neoplasms, including Hodgkin and other non-Hodgkin lymphomas, and even mesenchymal or epithelial lesions. In the current World Health Organization classification of hematopoietic tumors, all except 1 subtype (ie, T-lymphoblastic lymphoma) are recognized as mature neoplasms derived from postthymic T cells. In addition to T-lymphoblastic lymphoma, this review will focus on nodal and extranodal T-cell lymphomas and exclude T-cell lymphomas presenting primarily in the skin. Extranodal natural-killer-cell/T-cell lymphoma, nasal type, will also be discussed because the derivation of this lymphoma from natural killer and natural killer-like T cells shows morphologic and immunophenotypic features that overlap with other T-cell lymphomas. In this review, we discuss the salient clinicopathologic, immunophenotypic, and genetic features, as well as our approaches to the diagnosis of lymphoblastic, nodal, and extranodal T-cell lymphomas.
KW - Clonality
KW - Non-Hodgkin lymphoma
KW - T cells
KW - T-cell receptor gene rearrangement
UR - http://www.scopus.com/inward/record.url?scp=84875232177&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875232177&partnerID=8YFLogxK
U2 - 10.1016/j.humpath.2012.02.007
DO - 10.1016/j.humpath.2012.02.007
M3 - Article
C2 - 22658223
AN - SCOPUS:84875232177
SN - 0046-8177
VL - 44
SP - 451
EP - 471
JO - Human Pathology
JF - Human Pathology
IS - 4
ER -