The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events

E. H. Weiss, A. Mellor, L. Golden, K. Fahrner, E. Simpson, J. Hurst, R. A. Flavell

Research output: Contribution to journalArticle

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Abstract

We have cloned a mutant allele of the H-2Kb gene known as H-2Kbml. DNA sequence analysis of this gene shows that it is the result of an intergenic exchange of DNA (gene conversion) which results in the conversion of a short internal segment of the H-2Kb to the corresponding sequence of another H-2 gene. We suggest that this type of gene conversion is widespread in H-2 genes and that it is a major force in the generation of polymorphism in H-2 genes.

Original languageEnglish (US)
Pages (from-to)671-674
Number of pages4
JournalNature
Volume301
Issue number5902
DOIs
StatePublished - Dec 1 1983

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Gene Conversion
Genes
Intergenic DNA
DNA Sequence Analysis
Alleles

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Cite this

Weiss, E. H., Mellor, A., Golden, L., Fahrner, K., Simpson, E., Hurst, J., & Flavell, R. A. (1983). The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events. Nature, 301(5902), 671-674. https://doi.org/10.1038/301671a0

The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events. / Weiss, E. H.; Mellor, A.; Golden, L.; Fahrner, K.; Simpson, E.; Hurst, J.; Flavell, R. A.

In: Nature, Vol. 301, No. 5902, 01.12.1983, p. 671-674.

Research output: Contribution to journalArticle

Weiss, EH, Mellor, A, Golden, L, Fahrner, K, Simpson, E, Hurst, J & Flavell, RA 1983, 'The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events', Nature, vol. 301, no. 5902, pp. 671-674. https://doi.org/10.1038/301671a0
Weiss, E. H. ; Mellor, A. ; Golden, L. ; Fahrner, K. ; Simpson, E. ; Hurst, J. ; Flavell, R. A. / The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events. In: Nature. 1983 ; Vol. 301, No. 5902. pp. 671-674.
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