The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events

E. H. Weiss, A. Mellor, L. Golden, K. Fahrner, E. Simpson, J. Hurst, R. A. Flavell

Research output: Contribution to journalArticlepeer-review

167 Scopus citations

Abstract

We have cloned a mutant allele of the H-2Kb gene known as H-2Kbml. DNA sequence analysis of this gene shows that it is the result of an intergenic exchange of DNA (gene conversion) which results in the conversion of a short internal segment of the H-2Kb to the corresponding sequence of another H-2 gene. We suggest that this type of gene conversion is widespread in H-2 genes and that it is a major force in the generation of polymorphism in H-2 genes.

Original languageEnglish (US)
Pages (from-to)671-674
Number of pages4
JournalNature
Volume301
Issue number5902
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • General

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