The study of in vivo quantification of aluminum (Al) in human bone with a compact DD generator-based neutron activation analysis (NAA) system

Patrick Byrne, Farshad Mostafaei, Yingzi Liu, Scott P. Blake, David Koltick, Linda H. Nie

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The feasibility and methodology of using a compact DD generator-based neutron activation analysis system to measure aluminum in hand bone has been investigated. Monte Carlo simulations were used to simulate the moderator, reflector, and shielding assembly and to estimate the radiation dose. A high purity germanium (HPGe) detector was used to detect the Al gamma ray signals. The minimum detectable limit (MDL) was found to be 11.13 μg g-1 dry bone (ppm). An additional HPGe detector would improve the MDL by a factor of 1.4, to 7.9 ppm. The equivalent dose delivered to the irradiated hand was calculated by Monte Carlo to be 11.9 mSv. In vivo bone aluminum measurement with the DD generator was found to be feasible among general population with an acceptable dose to the subject.

Original languageEnglish (US)
Article number5649
Pages (from-to)649-660
Number of pages12
JournalPhysiological Measurement
Volume37
Issue number5
DOIs
StatePublished - Apr 18 2016
Externally publishedYes

Keywords

  • aluminum
  • neutron activation analysis
  • neutron generator

ASJC Scopus subject areas

  • Biophysics
  • Physiology
  • Biomedical Engineering
  • Physiology (medical)

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