The study of in vivo quantification of aluminum (Al) in human bone with a compact DD generator-based neutron activation analysis (NAA) system

Patrick Byrne; Farshad Mostafaei; Yingzi Liu; Scott P. Blake; David Koltick; Linda H. Nie

doi:10.1088/0967-3334/37/5/649

The study of in vivo quantification of aluminum (Al) in human bone with a compact DD generator-based neutron activation analysis (NAA) system

Patrick Byrne, Farshad Mostafaei, Yingzi Liu, Scott P. Blake, David Koltick, Linda H. Nie

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The feasibility and methodology of using a compact DD generator-based neutron activation analysis system to measure aluminum in hand bone has been investigated. Monte Carlo simulations were used to simulate the moderator, reflector, and shielding assembly and to estimate the radiation dose. A high purity germanium (HPGe) detector was used to detect the Al gamma ray signals. The minimum detectable limit (MDL) was found to be 11.13 μg g^-1 dry bone (ppm). An additional HPGe detector would improve the MDL by a factor of 1.4, to 7.9 ppm. The equivalent dose delivered to the irradiated hand was calculated by Monte Carlo to be 11.9 mSv. In vivo bone aluminum measurement with the DD generator was found to be feasible among general population with an acceptable dose to the subject.

Original language	English (US)
Article number	5649
Pages (from-to)	649-660
Number of pages	12
Journal	Physiological Measurement
Volume	37
Issue number	5
DOIs	https://doi.org/10.1088/0967-3334/37/5/649
State	Published - Apr 18 2016
Externally published	Yes

Keywords

aluminum
neutron activation analysis
neutron generator

ASJC Scopus subject areas

Biophysics
Physiology
Biomedical Engineering
Physiology (medical)

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10.1088/0967-3334/37/5/649

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title = "The study of in vivo quantification of aluminum (Al) in human bone with a compact DD generator-based neutron activation analysis (NAA) system",

abstract = "The feasibility and methodology of using a compact DD generator-based neutron activation analysis system to measure aluminum in hand bone has been investigated. Monte Carlo simulations were used to simulate the moderator, reflector, and shielding assembly and to estimate the radiation dose. A high purity germanium (HPGe) detector was used to detect the Al gamma ray signals. The minimum detectable limit (MDL) was found to be 11.13 μg g-1 dry bone (ppm). An additional HPGe detector would improve the MDL by a factor of 1.4, to 7.9 ppm. The equivalent dose delivered to the irradiated hand was calculated by Monte Carlo to be 11.9 mSv. In vivo bone aluminum measurement with the DD generator was found to be feasible among general population with an acceptable dose to the subject.",

keywords = "aluminum, neutron activation analysis, neutron generator",

author = "Patrick Byrne and Farshad Mostafaei and Yingzi Liu and Blake, {Scott P.} and David Koltick and Nie, {Linda H.}",

note = "Funding Information: This study was supported by the National Institute for Occupational Safety and Health (NIOSH) R21OH010044, the NIOSH Pilot Research Project Training Program of the University of Michigan Education and Research Center Grant, and the Purdue University Nuclear Regulatory Commission (NRC) Faculty Development Grant NRC-HQ-11-G-38-0006. Publisher Copyright: {\textcopyright} 2016 Institute of Physics and Engineering in Medicine.",

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doi = "10.1088/0967-3334/37/5/649",

language = "English (US)",

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AU - Byrne, Patrick

AU - Mostafaei, Farshad

AU - Liu, Yingzi

AU - Blake, Scott P.

AU - Koltick, David

AU - Nie, Linda H.

N1 - Funding Information: This study was supported by the National Institute for Occupational Safety and Health (NIOSH) R21OH010044, the NIOSH Pilot Research Project Training Program of the University of Michigan Education and Research Center Grant, and the Purdue University Nuclear Regulatory Commission (NRC) Faculty Development Grant NRC-HQ-11-G-38-0006. Publisher Copyright: © 2016 Institute of Physics and Engineering in Medicine.

PY - 2016/4/18

Y1 - 2016/4/18

N2 - The feasibility and methodology of using a compact DD generator-based neutron activation analysis system to measure aluminum in hand bone has been investigated. Monte Carlo simulations were used to simulate the moderator, reflector, and shielding assembly and to estimate the radiation dose. A high purity germanium (HPGe) detector was used to detect the Al gamma ray signals. The minimum detectable limit (MDL) was found to be 11.13 μg g-1 dry bone (ppm). An additional HPGe detector would improve the MDL by a factor of 1.4, to 7.9 ppm. The equivalent dose delivered to the irradiated hand was calculated by Monte Carlo to be 11.9 mSv. In vivo bone aluminum measurement with the DD generator was found to be feasible among general population with an acceptable dose to the subject.

AB - The feasibility and methodology of using a compact DD generator-based neutron activation analysis system to measure aluminum in hand bone has been investigated. Monte Carlo simulations were used to simulate the moderator, reflector, and shielding assembly and to estimate the radiation dose. A high purity germanium (HPGe) detector was used to detect the Al gamma ray signals. The minimum detectable limit (MDL) was found to be 11.13 μg g-1 dry bone (ppm). An additional HPGe detector would improve the MDL by a factor of 1.4, to 7.9 ppm. The equivalent dose delivered to the irradiated hand was calculated by Monte Carlo to be 11.9 mSv. In vivo bone aluminum measurement with the DD generator was found to be feasible among general population with an acceptable dose to the subject.

KW - aluminum

KW - neutron activation analysis

KW - neutron generator

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The study of in vivo quantification of aluminum (Al) in human bone with a compact DD generator-based neutron activation analysis (NAA) system

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Keywords

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