The Mγ chain of human fetal hemoglobin; its identification and occurrence

T. H.J. Huisman, Ferdane Kutlar, Abdullah Kutlar, J. B. Wilson, H. F. Harris

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Abstract

High-performance liquid chromatographic procedures have been used in the detection and identification of a new γ chain of human fetal hemoglobin (Hb). This Mγ chain is characterized by a Leu → Met replacement at position γ141; no other structural variations have been observed. The Mγ chain has been detected in red cell lysates of subjects with a heterozygosity for one of many types of so-called hereditary persistence of fetal hemoglobin conditions, which are characterized by an increased level of HB F in adult life, in sickle cell anemia, and in a few cord blood samples. At present it is not possible to definitely identify the genetic cause of this newly discovered heterogeneity; an infidelity in translation or the existence of an unrecognized γ globin gene should be considered.

Original languageEnglish (US)
Pages (from-to)429-439
Number of pages11
JournalJournal of Chromatography A
Volume388
Issue numberC
DOIs
StatePublished - Jan 1 1987

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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