The Mγ chain of human fetal hemoglobin; its identification and occurrence

T. H.J. Huisman; F. Kutlar; A. Kutlar; J. B. Wilson; H. F. Harris

doi:10.1016/S0021-9673(01)94503-0

The ^Mγ chain of human fetal hemoglobin; its identification and occurrence

T. H.J. Huisman, F. Kutlar, A. Kutlar, J. B. Wilson, H. F. Harris

Pulmonary Disease

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Abstract

High-performance liquid chromatographic procedures have been used in the detection and identification of a new γ chain of human fetal hemoglobin (Hb). This ^Mγ chain is characterized by a Leu → Met replacement at position γ141; no other structural variations have been observed. The ^Mγ chain has been detected in red cell lysates of subjects with a heterozygosity for one of many types of so-called hereditary persistence of fetal hemoglobin conditions, which are characterized by an increased level of HB F in adult life, in sickle cell anemia, and in a few cord blood samples. At present it is not possible to definitely identify the genetic cause of this newly discovered heterogeneity; an infidelity in translation or the existence of an unrecognized γ globin gene should be considered.

Original language	English (US)
Pages (from-to)	429-439
Number of pages	11
Journal	Journal of Chromatography A
Volume	388
Issue number	C
DOIs	https://doi.org/10.1016/S0021-9673(01)94503-0
State	Published - 1987

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Organic Chemistry

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title = "The Mγ chain of human fetal hemoglobin; its identification and occurrence",

abstract = "High-performance liquid chromatographic procedures have been used in the detection and identification of a new γ chain of human fetal hemoglobin (Hb). This Mγ chain is characterized by a Leu → Met replacement at position γ141; no other structural variations have been observed. The Mγ chain has been detected in red cell lysates of subjects with a heterozygosity for one of many types of so-called hereditary persistence of fetal hemoglobin conditions, which are characterized by an increased level of HB F in adult life, in sickle cell anemia, and in a few cord blood samples. At present it is not possible to definitely identify the genetic cause of this newly discovered heterogeneity; an infidelity in translation or the existence of an unrecognized γ globin gene should be considered.",

author = "Huisman, {T. H.J.} and F. Kutlar and A. Kutlar and Wilson, {J. B.} and Harris, {H. F.}",

note = "Funding Information: These studiesw ere supportedb y USPHS ResearchG rants HLB-29604 and HBL-29554.T his is contributionN o. 1014f rom the Departmento f Cell and Molecular Biology at the Medical Collegeo f Georgia in Augusta,G A, U.S.A.",

year = "1987",

doi = "10.1016/S0021-9673(01)94503-0",

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pages = "429--439",

journal = "Journal of Chromatography A",

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T1 - The Mγ chain of human fetal hemoglobin; its identification and occurrence

AU - Huisman, T. H.J.

AU - Kutlar, F.

AU - Kutlar, A.

AU - Wilson, J. B.

AU - Harris, H. F.

N1 - Funding Information: These studiesw ere supportedb y USPHS ResearchG rants HLB-29604 and HBL-29554.T his is contributionN o. 1014f rom the Departmento f Cell and Molecular Biology at the Medical Collegeo f Georgia in Augusta,G A, U.S.A.

PY - 1987

Y1 - 1987

N2 - High-performance liquid chromatographic procedures have been used in the detection and identification of a new γ chain of human fetal hemoglobin (Hb). This Mγ chain is characterized by a Leu → Met replacement at position γ141; no other structural variations have been observed. The Mγ chain has been detected in red cell lysates of subjects with a heterozygosity for one of many types of so-called hereditary persistence of fetal hemoglobin conditions, which are characterized by an increased level of HB F in adult life, in sickle cell anemia, and in a few cord blood samples. At present it is not possible to definitely identify the genetic cause of this newly discovered heterogeneity; an infidelity in translation or the existence of an unrecognized γ globin gene should be considered.

AB - High-performance liquid chromatographic procedures have been used in the detection and identification of a new γ chain of human fetal hemoglobin (Hb). This Mγ chain is characterized by a Leu → Met replacement at position γ141; no other structural variations have been observed. The Mγ chain has been detected in red cell lysates of subjects with a heterozygosity for one of many types of so-called hereditary persistence of fetal hemoglobin conditions, which are characterized by an increased level of HB F in adult life, in sickle cell anemia, and in a few cord blood samples. At present it is not possible to definitely identify the genetic cause of this newly discovered heterogeneity; an infidelity in translation or the existence of an unrecognized γ globin gene should be considered.

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