Abstract
High-performance liquid chromatographic procedures have been used in the detection and identification of a new γ chain of human fetal hemoglobin (Hb). This Mγ chain is characterized by a Leu → Met replacement at position γ141; no other structural variations have been observed. The Mγ chain has been detected in red cell lysates of subjects with a heterozygosity for one of many types of so-called hereditary persistence of fetal hemoglobin conditions, which are characterized by an increased level of HB F in adult life, in sickle cell anemia, and in a few cord blood samples. At present it is not possible to definitely identify the genetic cause of this newly discovered heterogeneity; an infidelity in translation or the existence of an unrecognized γ globin gene should be considered.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 429-439 |
| Number of pages | 11 |
| Journal | Journal of Chromatography A |
| Volume | 388 |
| Issue number | C |
| DOIs | |
| State | Published - Jan 1 1987 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Organic Chemistry
Cite this
The Mγ chain of human fetal hemoglobin; its identification and occurrence. / Huisman, T. H.J.; Kutlar, Ferdane; Kutlar, Abdullah; Wilson, J. B.; Harris, H. F.
In: Journal of Chromatography A, Vol. 388, No. C, 01.01.1987, p. 429-439.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Mγ chain of human fetal hemoglobin; its identification and occurrence
AU - Huisman, T. H.J.
AU - Kutlar, Ferdane
AU - Kutlar, Abdullah
AU - Wilson, J. B.
AU - Harris, H. F.
PY - 1987/1/1
Y1 - 1987/1/1
N2 - High-performance liquid chromatographic procedures have been used in the detection and identification of a new γ chain of human fetal hemoglobin (Hb). This Mγ chain is characterized by a Leu → Met replacement at position γ141; no other structural variations have been observed. The Mγ chain has been detected in red cell lysates of subjects with a heterozygosity for one of many types of so-called hereditary persistence of fetal hemoglobin conditions, which are characterized by an increased level of HB F in adult life, in sickle cell anemia, and in a few cord blood samples. At present it is not possible to definitely identify the genetic cause of this newly discovered heterogeneity; an infidelity in translation or the existence of an unrecognized γ globin gene should be considered.
AB - High-performance liquid chromatographic procedures have been used in the detection and identification of a new γ chain of human fetal hemoglobin (Hb). This Mγ chain is characterized by a Leu → Met replacement at position γ141; no other structural variations have been observed. The Mγ chain has been detected in red cell lysates of subjects with a heterozygosity for one of many types of so-called hereditary persistence of fetal hemoglobin conditions, which are characterized by an increased level of HB F in adult life, in sickle cell anemia, and in a few cord blood samples. At present it is not possible to definitely identify the genetic cause of this newly discovered heterogeneity; an infidelity in translation or the existence of an unrecognized γ globin gene should be considered.
UR - http://www.scopus.com/inward/record.url?scp=0023112974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023112974&partnerID=8YFLogxK
U2 - 10.1016/S0021-9673(01)94503-0
DO - 10.1016/S0021-9673(01)94503-0
M3 - Article
C2 - 2435748
AN - SCOPUS:0023112974
VL - 388
SP - 429
EP - 439
JO - Journal of Chromatography
JF - Journal of Chromatography
SN - 0021-9673
IS - C
ER -