The time dimension to stroke: Circadian effects on stroke outcomes and mechanisms

Pradip K. Kamat, Mohammad Badruzzaman Khan, Cameron Smith, Shahneela Siddiqui, Babak Baban, Krishnan Dhandapani, David C. Hess

Research output: Contribution to journalArticlepeer-review

Abstract

The circadian system is widely involved in the various pathological outcomes affected by time dimension changes. In the brain, the master circadian clock, also known as the “pacemaker,” is present in the hypothalamus's suprachiasmatic nucleus (SCN). The SCN consists of molecular circadian clocks that operate in each neuron and other brain cells. These circadian mechanisms are controlled by the transcription and translation of specific genes such as the clock circadian regulator (Clock) and brain and muscle ARNT-Like 1 (Bmal1). Period (Per1–3) and cryptochrome (Cry1 and 2) negatively feedback and regulate the clock genes. Variations in the circadian cycle and these clock genes can affect stroke outcomes. Studies suggest that the peak stroke occurs in the morning after patients awaken from sleep, while stroke severity and poor outcomes worsen at midnight. The main risk factor associated with stroke is high blood pressure (hypertension). Blood pressure usually dips by 15–20% during sleep, but many hypertensives do not display this normal dipping pattern and are non-dippers. A sleep blood pressure is the primary determinant of stroke risk. This article discusses the possible mechanism associated with circadian rhythm and stroke outcomes.

Original languageEnglish (US)
Article number105457
JournalNeurochemistry International
Volume162
DOIs
StatePublished - Jan 2023

Keywords

  • Aging
  • Circadian rhythm
  • Clock gene
  • Diabetes
  • Hypertension
  • Inflammation
  • Stroke

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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