The tumor necrosis factor-derived TIP peptide: A potential anti-edema drug

Rudolf Lucas, Harald Hundsberger, Maren Pflüger, Bernhard Fischer, Denis Morel, Clemens Braun, Albrecht Wendel, Trinad Chakraborty, Wolfgang Schütt, Christoph Wiesner, Jürg Hamacher

Research output: Contribution to journalReview article

Abstract

In view of the significant side-effects of existing substances as well as of supportive therapies for the treatment of pulmonary edema, there is a renewed search for novel drugs that increase the uptake of sodium in type II alveolar epithelial cells, a phenomenon which is crucial for lung liquid clearance. We describe here the discovery and characterization of a Tumor Necrosis Factor (TNF)-derived peptide mimicking the lectin-like domain of the cytokine as a potential novel anti-edema agent.

Original languageEnglish (US)
Pages (from-to)336-340
Number of pages5
JournalLetters in Drug Design and Discovery
Volume4
Issue number5
DOIs
Publication statusPublished - Jul 1 2007
Externally publishedYes

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Keywords

  • Lectin
  • Peptide
  • Pulmonary edema
  • Sodium channels
  • TNF

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Lucas, R., Hundsberger, H., Pflüger, M., Fischer, B., Morel, D., Braun, C., ... Hamacher, J. (2007). The tumor necrosis factor-derived TIP peptide: A potential anti-edema drug. Letters in Drug Design and Discovery, 4(5), 336-340. https://doi.org/10.2174/157018007780867816