Abstract
In view of the significant side-effects of existing substances as well as of supportive therapies for the treatment of pulmonary edema, there is a renewed search for novel drugs that increase the uptake of sodium in type II alveolar epithelial cells, a phenomenon which is crucial for lung liquid clearance. We describe here the discovery and characterization of a Tumor Necrosis Factor (TNF)-derived peptide mimicking the lectin-like domain of the cytokine as a potential novel anti-edema agent.
Original language | English (US) |
---|---|
Pages (from-to) | 336-340 |
Number of pages | 5 |
Journal | Letters in Drug Design and Discovery |
Volume | 4 |
Issue number | 5 |
DOIs | |
State | Published - Jul 2007 |
Externally published | Yes |
Keywords
- Lectin
- Peptide
- Pulmonary edema
- Sodium channels
- TNF
ASJC Scopus subject areas
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery