The tumor necrosis factor-derived TIP peptide: A potential anti-edema drug

Rudolf Lucas, Harald Hundsberger, Maren Pflüger, Bernhard Fischer, Denis Morel, Clemens Braun, Albrecht Wendel, Trinad Chakraborty, Wolfgang Schütt, Christoph Wiesner, Jürg Hamacher

Research output: Contribution to journalReview article

Abstract

In view of the significant side-effects of existing substances as well as of supportive therapies for the treatment of pulmonary edema, there is a renewed search for novel drugs that increase the uptake of sodium in type II alveolar epithelial cells, a phenomenon which is crucial for lung liquid clearance. We describe here the discovery and characterization of a Tumor Necrosis Factor (TNF)-derived peptide mimicking the lectin-like domain of the cytokine as a potential novel anti-edema agent.

Original languageEnglish (US)
Pages (from-to)336-340
Number of pages5
JournalLetters in Drug Design and Discovery
Volume4
Issue number5
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

Fingerprint

Alveolar Epithelial Cells
Pulmonary Edema
Lectins
Edema
Tumor Necrosis Factor-alpha
Sodium
Cytokines
Lung
Peptides
Pharmaceutical Preparations
Therapeutics
peptide A

Keywords

  • Lectin
  • Peptide
  • Pulmonary edema
  • Sodium channels
  • TNF

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Lucas, R., Hundsberger, H., Pflüger, M., Fischer, B., Morel, D., Braun, C., ... Hamacher, J. (2007). The tumor necrosis factor-derived TIP peptide: A potential anti-edema drug. Letters in Drug Design and Discovery, 4(5), 336-340. https://doi.org/10.2174/157018007780867816

The tumor necrosis factor-derived TIP peptide : A potential anti-edema drug. / Lucas, Rudolf; Hundsberger, Harald; Pflüger, Maren; Fischer, Bernhard; Morel, Denis; Braun, Clemens; Wendel, Albrecht; Chakraborty, Trinad; Schütt, Wolfgang; Wiesner, Christoph; Hamacher, Jürg.

In: Letters in Drug Design and Discovery, Vol. 4, No. 5, 01.07.2007, p. 336-340.

Research output: Contribution to journalReview article

Lucas, R, Hundsberger, H, Pflüger, M, Fischer, B, Morel, D, Braun, C, Wendel, A, Chakraborty, T, Schütt, W, Wiesner, C & Hamacher, J 2007, 'The tumor necrosis factor-derived TIP peptide: A potential anti-edema drug', Letters in Drug Design and Discovery, vol. 4, no. 5, pp. 336-340. https://doi.org/10.2174/157018007780867816
Lucas, Rudolf ; Hundsberger, Harald ; Pflüger, Maren ; Fischer, Bernhard ; Morel, Denis ; Braun, Clemens ; Wendel, Albrecht ; Chakraborty, Trinad ; Schütt, Wolfgang ; Wiesner, Christoph ; Hamacher, Jürg. / The tumor necrosis factor-derived TIP peptide : A potential anti-edema drug. In: Letters in Drug Design and Discovery. 2007 ; Vol. 4, No. 5. pp. 336-340.
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