The ubiquitin-proteasome system in cardiac proteinopathy: A quality control perspective

Huabo Su, Xuejun Wang

Research output: Contribution to journalReview article

80 Scopus citations

Abstract

Protein quality control (PQC) depends on elegant collaboration between molecular chaperones and targeted proteolysis in the cell. The latter is primarily carried out by the ubiquitin-proteasome system, but recent advances in this area of research suggest a supplementary role for the autophagy-lysosomal pathway in PQC-related proteolysis. The (patho)physiological significance of PQC in the heart is best illustrated in cardiac proteinopathy, which belongs to a family of cardiac diseases caused by expression of aggregation-prone proteins in cardiomyocytes. Cardiac proteasome functional insufficiency (PFI) is best studied in desmin-related cardiomyopathy, a bona fide cardiac proteinopathy. Emerging evidence suggests that many common forms of cardiomyopathy may belong to proteinopathy. This review focuses on examining current evidence, as it relates to the hypothesis that PFI impairs PQC in cardiomyocytes and contributes to the progression of cardiac proteinopathies to heart failure.

Original languageEnglish (US)
Pages (from-to)253-262
Number of pages10
JournalCardiovascular Research
Volume85
Issue number2
DOIs
StatePublished - Jan 2010
Externally publishedYes

Keywords

  • Autophagy
  • Chaperone
  • Desmin-related cardiomyopathy
  • Proteasome
  • Protein quality control
  • Ubiquitin

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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