The UFMylation System in Proteostasis and Beyond

Yannis Gerakis, Michaela Quintero, Honglin Li, Claudio Hetz

Research output: Contribution to journalReview article

Abstract

Post-translational modifications are at the apex of cellular communication and eventually regulate every aspect of life. The identification of new post-translational modifiers is opening alternative avenues in understanding fundamental cell biology processes and may ultimately provide novel therapeutic opportunities. The ubiquitin-fold modifier 1 (UFM1) is a post-translational modifier discovered a decade ago but its biological significance has remained mostly unknown. The field has recently witnessed an explosion of research uncovering the implications of the pathway to cellular homeostasis in living organisms. We overview recent advances in the function and regulation of the UFM1 pathway, and its implications for cell physiology and disease.

Original languageEnglish (US)
Pages (from-to)974-986
Number of pages13
JournalTrends in Cell Biology
Volume29
Issue number12
DOIs
StatePublished - Dec 2019

Fingerprint

Ubiquitin
Cell Physiological Phenomena
Explosions
Post Translational Protein Processing
Cell Biology
Homeostasis
Research
Therapeutics

Keywords

  • ER stress
  • proteostasis
  • UBL
  • UFM1
  • UPR

ASJC Scopus subject areas

  • Cell Biology

Cite this

The UFMylation System in Proteostasis and Beyond. / Gerakis, Yannis; Quintero, Michaela; Li, Honglin; Hetz, Claudio.

In: Trends in Cell Biology, Vol. 29, No. 12, 12.2019, p. 974-986.

Research output: Contribution to journalReview article

Gerakis, Yannis ; Quintero, Michaela ; Li, Honglin ; Hetz, Claudio. / The UFMylation System in Proteostasis and Beyond. In: Trends in Cell Biology. 2019 ; Vol. 29, No. 12. pp. 974-986.
@article{e65d5dfffa2e48aaa10c1ef5ddce9151,
title = "The UFMylation System in Proteostasis and Beyond",
abstract = "Post-translational modifications are at the apex of cellular communication and eventually regulate every aspect of life. The identification of new post-translational modifiers is opening alternative avenues in understanding fundamental cell biology processes and may ultimately provide novel therapeutic opportunities. The ubiquitin-fold modifier 1 (UFM1) is a post-translational modifier discovered a decade ago but its biological significance has remained mostly unknown. The field has recently witnessed an explosion of research uncovering the implications of the pathway to cellular homeostasis in living organisms. We overview recent advances in the function and regulation of the UFM1 pathway, and its implications for cell physiology and disease.",
keywords = "ER stress, proteostasis, UBL, UFM1, UPR",
author = "Yannis Gerakis and Michaela Quintero and Honglin Li and Claudio Hetz",
year = "2019",
month = "12",
doi = "10.1016/j.tcb.2019.09.005",
language = "English (US)",
volume = "29",
pages = "974--986",
journal = "Trends in Cell Biology",
issn = "0962-8924",
publisher = "Elsevier Limited",
number = "12",

}

TY - JOUR

T1 - The UFMylation System in Proteostasis and Beyond

AU - Gerakis, Yannis

AU - Quintero, Michaela

AU - Li, Honglin

AU - Hetz, Claudio

PY - 2019/12

Y1 - 2019/12

N2 - Post-translational modifications are at the apex of cellular communication and eventually regulate every aspect of life. The identification of new post-translational modifiers is opening alternative avenues in understanding fundamental cell biology processes and may ultimately provide novel therapeutic opportunities. The ubiquitin-fold modifier 1 (UFM1) is a post-translational modifier discovered a decade ago but its biological significance has remained mostly unknown. The field has recently witnessed an explosion of research uncovering the implications of the pathway to cellular homeostasis in living organisms. We overview recent advances in the function and regulation of the UFM1 pathway, and its implications for cell physiology and disease.

AB - Post-translational modifications are at the apex of cellular communication and eventually regulate every aspect of life. The identification of new post-translational modifiers is opening alternative avenues in understanding fundamental cell biology processes and may ultimately provide novel therapeutic opportunities. The ubiquitin-fold modifier 1 (UFM1) is a post-translational modifier discovered a decade ago but its biological significance has remained mostly unknown. The field has recently witnessed an explosion of research uncovering the implications of the pathway to cellular homeostasis in living organisms. We overview recent advances in the function and regulation of the UFM1 pathway, and its implications for cell physiology and disease.

KW - ER stress

KW - proteostasis

KW - UBL

KW - UFM1

KW - UPR

UR - http://www.scopus.com/inward/record.url?scp=85075032940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075032940&partnerID=8YFLogxK

U2 - 10.1016/j.tcb.2019.09.005

DO - 10.1016/j.tcb.2019.09.005

M3 - Review article

C2 - 31703843

AN - SCOPUS:85075032940

VL - 29

SP - 974

EP - 986

JO - Trends in Cell Biology

JF - Trends in Cell Biology

SN - 0962-8924

IS - 12

ER -