Abstract
Post-translational modifications are at the apex of cellular communication and eventually regulate every aspect of life. The identification of new post-translational modifiers is opening alternative avenues in understanding fundamental cell biology processes and may ultimately provide novel therapeutic opportunities. The ubiquitin-fold modifier 1 (UFM1) is a post-translational modifier discovered a decade ago but its biological significance has remained mostly unknown. The field has recently witnessed an explosion of research uncovering the implications of the pathway to cellular homeostasis in living organisms. We overview recent advances in the function and regulation of the UFM1 pathway, and its implications for cell physiology and disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 974-986 |
| Number of pages | 13 |
| Journal | Trends in Cell Biology |
| Volume | 29 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2019 |
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Keywords
- ER stress
- proteostasis
- UBL
- UFM1
- UPR
ASJC Scopus subject areas
- Cell Biology
Cite this
The UFMylation System in Proteostasis and Beyond. / Gerakis, Yannis; Quintero, Michaela; Li, Honglin; Hetz, Claudio.
In: Trends in Cell Biology, Vol. 29, No. 12, 12.2019, p. 974-986.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The UFMylation System in Proteostasis and Beyond
AU - Gerakis, Yannis
AU - Quintero, Michaela
AU - Li, Honglin
AU - Hetz, Claudio
PY - 2019/12
Y1 - 2019/12
N2 - Post-translational modifications are at the apex of cellular communication and eventually regulate every aspect of life. The identification of new post-translational modifiers is opening alternative avenues in understanding fundamental cell biology processes and may ultimately provide novel therapeutic opportunities. The ubiquitin-fold modifier 1 (UFM1) is a post-translational modifier discovered a decade ago but its biological significance has remained mostly unknown. The field has recently witnessed an explosion of research uncovering the implications of the pathway to cellular homeostasis in living organisms. We overview recent advances in the function and regulation of the UFM1 pathway, and its implications for cell physiology and disease.
AB - Post-translational modifications are at the apex of cellular communication and eventually regulate every aspect of life. The identification of new post-translational modifiers is opening alternative avenues in understanding fundamental cell biology processes and may ultimately provide novel therapeutic opportunities. The ubiquitin-fold modifier 1 (UFM1) is a post-translational modifier discovered a decade ago but its biological significance has remained mostly unknown. The field has recently witnessed an explosion of research uncovering the implications of the pathway to cellular homeostasis in living organisms. We overview recent advances in the function and regulation of the UFM1 pathway, and its implications for cell physiology and disease.
KW - ER stress
KW - proteostasis
KW - UBL
KW - UFM1
KW - UPR
UR - http://www.scopus.com/inward/record.url?scp=85075032940&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075032940&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2019.09.005
DO - 10.1016/j.tcb.2019.09.005
M3 - Review article
C2 - 31703843
AN - SCOPUS:85075032940
VL - 29
SP - 974
EP - 986
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 12
ER -