@article{e65d5dfffa2e48aaa10c1ef5ddce9151,
title = "The UFMylation System in Proteostasis and Beyond",
abstract = "Post-translational modifications are at the apex of cellular communication and eventually regulate every aspect of life. The identification of new post-translational modifiers is opening alternative avenues in understanding fundamental cell biology processes and may ultimately provide novel therapeutic opportunities. The ubiquitin-fold modifier 1 (UFM1) is a post-translational modifier discovered a decade ago but its biological significance has remained mostly unknown. The field has recently witnessed an explosion of research uncovering the implications of the pathway to cellular homeostasis in living organisms. We overview recent advances in the function and regulation of the UFM1 pathway, and its implications for cell physiology and disease.",
keywords = "ER stress, UBL, UFM1, UPR, proteostasis",
author = "Yannis Gerakis and Michaela Quintero and Honglin Li and Claudio Hetz",
note = "Funding Information: This work was directly funded by the Fondo Nacional de Desarrollo Cient{\'i}fico y Tecnol{\'o}gico (FONDECYT) 3080702 (to Y.G.); FONDAP program 15150012, Millennium Institute P09-015-F, Comisi{\'o}n Nacional de Investigaci{\'o}n Cient{\'i}fica y Tecnol{\'o}gica (CONICYT) Brazil 441921/2016-7, the Fondo de Fomento al Desarrollo Cient{\'i}fico y Tecnol{\'o}gico (FONDEF) ID16I10223 and D11E1007 , and FONDECYT 1180186 (to C.H.). In addition, we thank the support from the US Air Force Office of Scientific Research FA9550-16-1-0384, the Muscular Dystrophy Association , the US Office of Naval Research-Global (ONR-G) N62909-16-1-2003 (to C.H.), and the National Institutes of Health (NIH)/ National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 1R01DK113409 (to H.L.). Funding Information: This work was directly funded by the Fondo Nacional de Desarrollo Cient?fico y Tecnol?gico (FONDECYT) 3080702 (to Y.G.); FONDAP program 15150012, Millennium Institute P09-015-F, Comisi?n Nacional de Investigaci?n Cient?fica y Tecnol?gica (CONICYT) Brazil 441921/2016-7, the Fondo de Fomento al Desarrollo Cient?fico y Tecnol?gico (FONDEF) ID16I10223 and D11E1007, and FONDECYT 1180186 (to C.H.). In addition, we thank the support from the US Air Force Office of Scientific Research FA9550-16-1-0384, the Muscular Dystrophy Association, the US Office of Naval Research-Global (ONR-G) N62909-16-1-2003 (to C.H.), and the National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 1R01DK113409 (to H.L.).",
year = "2019",
month = dec,
doi = "10.1016/j.tcb.2019.09.005",
language = "English (US)",
volume = "29",
pages = "974--986",
journal = "Trends in Cell Biology",
issn = "0962-8924",
publisher = "Elsevier Limited",
number = "12",
}