The Use of Hyaluronic Acid Polymers to Reduce Postoperative Adhesions

David A. Grainger, William R. Meyer, Alan H. Decherney, Michael Peter Diamond

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The use of adjuvant therapy in an attempt to prevent adhesion formation and reformation is widely practiced. Proteoglycans, such as heparin, heparan, chondroitin sulfate, and others, have been shown, at least in experimental models, to decrease adhesion development. This study examines the ability of another proteoglycan, hyaluronic acid (HA) polymers (Pharmacia AB, Sweden), in four different formulations, to reduce adhesion formation in a rabbit model. New Zealand white rabbits underwent a midline laparotomy with bilateral ovarian bisection and were randomized to four treatment groups. Groups 1, 2, and 3 consisted of viscous solutions of HA polymers of differing molecular weights (2 ml applied to the treated ovary), and group 4 consisted of a polymer slab (2 × 2 cm piece applied to the treated ovary). The animals were killed 10–14 days after the initial laparotomy, and the adhesions were scored by a blinded observer. None of the formulations of HA solutions resulted in a reduction of ovarian adhesions. Only the polymer slab significantly reduced adhesion formation.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalJournal of Gynecologic Surgery
Volume7
Issue number2
DOIs
StatePublished - Jan 1 1991

Fingerprint

Hyaluronic Acid
Polymers
Proteoglycans
Laparotomy
Ovary
Rabbits
Heparitin Sulfate
Chondroitin Sulfates
Sweden
Heparin
Theoretical Models
Molecular Weight
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

Cite this

The Use of Hyaluronic Acid Polymers to Reduce Postoperative Adhesions. / Grainger, David A.; Meyer, William R.; Decherney, Alan H.; Diamond, Michael Peter.

In: Journal of Gynecologic Surgery, Vol. 7, No. 2, 01.01.1991, p. 97-101.

Research output: Contribution to journalArticle

Grainger, David A. ; Meyer, William R. ; Decherney, Alan H. ; Diamond, Michael Peter. / The Use of Hyaluronic Acid Polymers to Reduce Postoperative Adhesions. In: Journal of Gynecologic Surgery. 1991 ; Vol. 7, No. 2. pp. 97-101.
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