The use of pharmacogenomics for selection of therapy in Non-Small-Cell lung cancer

Nagla A. Karim, Hai Bui, Peterson Pathrose, Sandra Starnes, Ninad Patil, Mahmoud Shehata, Ahmed Mostafa, M. B. Rao, Ahmad Zarzour, Marshall Anderson

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Introduction: Performance status (PS) is the only known clinical predictor of outcome in patients with advanced non-small-cell lung cancer (NSCLC), although pharmacogenomic markers may also correlate with outcome. The aim of our study was to correlate clinical and pharmacogenomic measures with overall survival.

Methods: This was an IRB approved, retrospective study in which the medical records of 50 patients with advanced NSCLC from 1998–2008 were reviewed, and gender, race, PS, and chemotherapy regimens were documented. Stromal expression of pharmacogenomic markers (VEGFR, ERCC1, 14-3-3σ, pAKT, and PTEN) was measured. Clinical factors and pharmacogenomics markers were compared to overall survival using a Cox proportional hazards model.

Results: Forty patients received platinum-based therapy. Median age was 65 years. Improved PS, female gender, and gemcitabine therapy were signifi-cantly associated with longer overall survival (P = 0.004, P = 0.04, and P = 0.003, respectively). Age was not associated with survival. Caucasians had better overall survival in comparison to African Americans with median survival of 14.8 months versus 10.4 months (P = 0.1). Patients treated with platinum-based therapy had better survival of 15 months versus 8 months for non-platinum based therapy (P = 0.01). There was no significant association between any of the pharmacogenomics markers and overall survival other than in patients treated with platinum, in whom ERCC1 negativity was strongly associated with longer survival (P = 0.007).

Conclusion: ERCC1 negativity with platinum therapy, gemcitabine therapy, good PS, and female gender all correlated with improved overall survival in patients with advanced NSCLC.

Original languageEnglish (US)
Pages (from-to)139-144
Number of pages6
JournalClinical Medicine Insights: Oncology
Volume8
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Non-small-cell lung cancer
  • Pharmacogenomics
  • Selection of therapy

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Karim, N. A., Bui, H., Pathrose, P., Starnes, S., Patil, N., Shehata, M., Mostafa, A., Rao, M. B., Zarzour, A., & Anderson, M. (2014). The use of pharmacogenomics for selection of therapy in Non-Small-Cell lung cancer. Clinical Medicine Insights: Oncology, 8, 139-144. https://doi.org/10.4137/CMO.S18369