The vasopressor response to centrally administered ouabain

Robert William Caldwell, E. Songu-Mize, S. L. Bealer

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Ouabain (80 μg/kg) injected into the lateral cerebroventricles (ICV) of rats produced a prompt and sustained increase in arterial blood pressure. A diastolic blood pressure increase of about 40 mm Hg began within 10 minutes of injection and lasted at least 1 hour. This dose of ouabain had no effect on arterial pressure when given intravenously. The vasopressor response to intracerebroventricularly administered ouabain was not blocked by prior intravenous administration of phentolamine (1 mg/kg) or hexamethonium (3 mg/kg). However, continuous intravenous infusion of saralasin (2 μg/kg per min) prevented the pressor response to intracerebroventricularly administered ouabain. In addition, bilateral nephrectomy, adrenalectomy, pretreatment with intravenously administered propranolol (2 mg/kg) or captopril (10 mg/kg) abolished the increase in blood pressure evoked by intracerebroventricularly administered ouabain. Plasma renin and epinephrine levels at the peak of the pressor response to intracerebroventricularly administered ouabain were respectively, about 2.5- and 2-fold higher than in control rats. Our data indicate that ouabain administered into the central nervous system produces a hypertensive effect which does not primarily involve peripheral α-adrenergic receptors, but appears to be due to angiotensin II produced by renin of renal origin. These data suggest that digitalis agents can interact with sites in the central nervous system to induce a release of renin from the kidney; this release appears to involve activation of β-adrenergic receptors by catecholamines from the adrenal medulla, perhaps through a direct adrenal-kidney vascular network.

Original languageEnglish (US)
Pages (from-to)773-779
Number of pages7
JournalCirculation research
Volume55
Issue number6
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Ouabain
Renin
Blood Pressure
Kidney
Adrenergic Receptors
Arterial Pressure
Central Nervous System
Saralasin
Hexamethonium
Adrenal Medulla
Digitalis
Phentolamine
Captopril
Adrenalectomy
Nephrectomy
Intravenous Infusions
Propranolol
Angiotensin II
Intravenous Administration
Epinephrine

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

The vasopressor response to centrally administered ouabain. / Caldwell, Robert William; Songu-Mize, E.; Bealer, S. L.

In: Circulation research, Vol. 55, No. 6, 01.01.1984, p. 773-779.

Research output: Contribution to journalArticle

Caldwell, Robert William ; Songu-Mize, E. ; Bealer, S. L. / The vasopressor response to centrally administered ouabain. In: Circulation research. 1984 ; Vol. 55, No. 6. pp. 773-779.
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