The Verbal IQ/Performance IQ discrepancy as a sign of seizure focus laterality in pediatric patients with epilepsy

Lynn B. Blackburn, Gregory P Lee, Michael Westerveld, Ann Hempel, Yong D Park, David W. Loring

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A large Verbal IQ (VIQ)/Performance IQ (PIQ) discrepancy has been viewed as a sign of lateralized brain dysfunction. The current study was conducted to determine if the presence of a large VIQ/PIQ discrepancy (≥15 points) would accurately predict laterality of seizure foci in pediatric patients with epilepsy. A discrepancy score (VIQ - PIQ) was calculated for 130 children (mean age = 12.25) undergoing presurgical epilepsy evaluations. Patients were grouped on the basis of language mediation confirmed through the intracarotid amobarbital procedure. Large discrepancies were noted in 34% of the group with typical language and 24% of the children with atypical language organization. When present, this discrepancy accurately lateralized seizure focus for 79% of those with typical and 57% of those with atypical language organization. The presence of the discrepancy was unrelated to seizure control following surgery for the atypical language group. In the typical language group, 85% of children with discrepancies, but only 63% of children without discrepancies, achieved seizure control. Results suggest that the presence of a large discrepancy is not effective, by itself, in lateralizing seizure foci, but may contribute to refining predictions of surgical outcome.

Original languageEnglish (US)
Pages (from-to)84-88
Number of pages5
JournalEpilepsy and Behavior
Volume10
Issue number1
DOIs
StatePublished - Feb 1 2007

Fingerprint

Epilepsy
Seizures
Language
Pediatrics
Amobarbital
Child Language
Brain

Keywords

  • Childhood seizures
  • Epilepsy
  • Intelligence
  • Presurgical evaluation
  • Surgical outcome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this

The Verbal IQ/Performance IQ discrepancy as a sign of seizure focus laterality in pediatric patients with epilepsy. / Blackburn, Lynn B.; Lee, Gregory P; Westerveld, Michael; Hempel, Ann; Park, Yong D; Loring, David W.

In: Epilepsy and Behavior, Vol. 10, No. 1, 01.02.2007, p. 84-88.

Research output: Contribution to journalArticle

Blackburn, Lynn B. ; Lee, Gregory P ; Westerveld, Michael ; Hempel, Ann ; Park, Yong D ; Loring, David W. / The Verbal IQ/Performance IQ discrepancy as a sign of seizure focus laterality in pediatric patients with epilepsy. In: Epilepsy and Behavior. 2007 ; Vol. 10, No. 1. pp. 84-88.
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