The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight

Jianchao Xu, Pandelakis Koni, Peili Wang, Guoyong Li, Leonard Kaczmarek, Yanling Wu, Yanyan Li, Richard A. Flavell, Gary V. Desir

Research output: Contribution to journalArticle

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Abstract

Voltage-gated potassium (Kv) channels regulate cell membrane potential and control a variety of cellular processes. Kv1.3 channels are expressed in several tissues and believed to participate in cell volume regulation, apoptosis, T cell activation and renal solute homeostasis. Examination of Kv1.3-deficient mice (Kv1.3-/-), generated by gene targeting, revealed a previously unrecognized role for Kv1.3 in body weight regulation. Indeed, Kv1.3-/- mice weigh significantly less than control littermates. Moreover, knockout mice are protected from diet-induced obesity and gain significantly less weight than littermate controls when placed on a high-fat diet. While food intake did not differ significantly between Kv1.3-/- and controls, basal metabolic rate, measured at rest by indirect calorimetry, was significantly higher in knockout animals. These data indicate that Kv1.3 channels may participate in the pathways that regulate body weight and that channel inhibition increases basal metabolic rate.

Original languageEnglish (US)
Pages (from-to)551-559
Number of pages9
JournalHuman Molecular Genetics
Volume12
Issue number5
DOIs
StatePublished - Mar 1 2003

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Voltage-Gated Potassium Channels
Homeostasis
Body Weight
Basal Metabolism
Indirect Calorimetry
Gene Targeting
High Fat Diet
Cell Size
Knockout Mice
Membrane Potentials
Obesity
Eating
Cell Membrane
Apoptosis
Diet
T-Lymphocytes
Kidney
Weights and Measures

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Xu, J., Koni, P., Wang, P., Li, G., Kaczmarek, L., Wu, Y., ... Desir, G. V. (2003). The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Human Molecular Genetics, 12(5), 551-559. https://doi.org/10.1093/hmg/ddg049

The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. / Xu, Jianchao; Koni, Pandelakis; Wang, Peili; Li, Guoyong; Kaczmarek, Leonard; Wu, Yanling; Li, Yanyan; Flavell, Richard A.; Desir, Gary V.

In: Human Molecular Genetics, Vol. 12, No. 5, 01.03.2003, p. 551-559.

Research output: Contribution to journalArticle

Xu, J, Koni, P, Wang, P, Li, G, Kaczmarek, L, Wu, Y, Li, Y, Flavell, RA & Desir, GV 2003, 'The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight', Human Molecular Genetics, vol. 12, no. 5, pp. 551-559. https://doi.org/10.1093/hmg/ddg049
Xu, Jianchao ; Koni, Pandelakis ; Wang, Peili ; Li, Guoyong ; Kaczmarek, Leonard ; Wu, Yanling ; Li, Yanyan ; Flavell, Richard A. ; Desir, Gary V. / The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. In: Human Molecular Genetics. 2003 ; Vol. 12, No. 5. pp. 551-559.
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