Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles in Cardioprotection and Myocardium Repair

Bin Yu, Muhammad Ashraf, Meifeng Xu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Stem cell therapy research has demonstrated very promising results for regeneration of ischemic myocardium. The role of extracellular vesicles (EVs) in the restoration of cell structure and function is not fully understood. EVs are relatively complex biological entities that contain a range of biological molecules, including proteins, mRNA, and miRs. EVs are rapidly internalized by recipient cells and can activate multiple cardioprotective pathways through transfer of their cargo. Study of this critical component of endogenous repair therefore has the potential to provide not only insight into the mechanisms for existing therapies, but also more predictive information on new and more powerful cell-based treatments with fewer clinical pitfalls.

Original languageEnglish (US)
Title of host publicationMesenchymal Stem Cell Derived Exosomes
Subtitle of host publicationThe Potential for Translational Nanomedicine
PublisherElsevier Inc.
Pages1-20
Number of pages20
ISBN (Electronic)9780128004975
ISBN (Print)9780128001646
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Cardioprotection
  • Extracellular vesicles
  • MiRs
  • Paracrine effect
  • Stem cell

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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