Therapeutic Targeting of Astrocytes After Traumatic Brain Injury

Jessica Shields, Donald E. Kimbler, Walid Radwan, Nathan Eugene Yanasak, Sangeetha Sukumari Ramesh, Krishnan Michael Dhandapani

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Traumatic brain injury (TBI) remains a leading cause of mortality and morbidity worldwide. A major focus of preclinical research has focused on understanding the mechanisms of acute cell death after TBI; however, translation of these findings into the clinic has failed to improve long-term patient outcomes. Recent work suggests astrocytes, the predominant cell type within the human brain, may actively contribute to neurological demise by exacerbating secondary brain injury after TBI. Along these lines, astrocytes may promote neuroinflammation, increase the development of cerebral edema, and contribute to elevated intracranial pressure after brain injury. The primary goal of this mini-review is to summarize the growing body of literature that suggests reactive astrocytes influence the brain response to TBI. To maintain focus, we will limit our discussion to the mechanisms of cerebral edema.

Original languageEnglish (US)
Pages (from-to)633-642
Number of pages10
JournalTranslational Stroke Research
Volume2
Issue number4
DOIs
StatePublished - Dec 1 2011

Keywords

  • Aquaporin
  • Cerebral blood flow
  • ICP
  • Inflammation
  • Intracranial pressure
  • Neurotrauma

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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