Thermodynamic-geometric correlations for the morphology of self-assembled structures of glycosphingolipids and their mixtures with dipalmitoylphosphatidylcholine

Bruno Maggio, John Albert, Robert K. Yu

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61 Citations (Scopus)

Abstract

The morphology of aqueous dispersions of five neutral glycosphingolipids (GalCer, GlcCer, LacCer, asialo-GM2, asialo-GM1), sulfatide, and five gangliosides (GM3, GM2, GM1, GD1a and Gt1b) and their mixtures with dipalmitoylphosphatidylcholine was studied by negative staining electron microscopy. The morphological features are interpreted on the basis of thermodynamic and geometric constraints previously studied in these systems (Maggio, B (1985) Biochim. Biophys. Acta 815, 245-258). The correlation between the theoretical predictions and the experimental findings are in reasonable agreement. Small changes in tge molecular parameters of the individual glycosphingolipids or in their proportion in mixtures with dipalmitoylphosphatidylcholine bring about remarkable variations on the type of structure formed, its radius of curvature and thermodynamic stability.

Original languageEnglish (US)
Pages (from-to)145-160
Number of pages16
JournalBBA - Biomembranes
Volume945
Issue number2
DOIs
StatePublished - Nov 22 1988

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1,2-Dipalmitoylphosphatidylcholine
Glycosphingolipids
Thermodynamics
Neutral Glycosphingolipids
G(M2) Ganglioside
G(M3) Ganglioside
Sulfoglycosphingolipids
Negative Staining
Dispersions
Electron microscopy
Electron Microscopy
Thermodynamic stability
ganglio-N-triaosylceramide
asialo GM1 ganglioside

Keywords

  • Dipalmitoylphosphatidylcholine
  • Ganglioside
  • Geometrics
  • Glycosphingolipid
  • Membrane morphology
  • Thermodynamics

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

Cite this

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title = "Thermodynamic-geometric correlations for the morphology of self-assembled structures of glycosphingolipids and their mixtures with dipalmitoylphosphatidylcholine",
abstract = "The morphology of aqueous dispersions of five neutral glycosphingolipids (GalCer, GlcCer, LacCer, asialo-GM2, asialo-GM1), sulfatide, and five gangliosides (GM3, GM2, GM1, GD1a and Gt1b) and their mixtures with dipalmitoylphosphatidylcholine was studied by negative staining electron microscopy. The morphological features are interpreted on the basis of thermodynamic and geometric constraints previously studied in these systems (Maggio, B (1985) Biochim. Biophys. Acta 815, 245-258). The correlation between the theoretical predictions and the experimental findings are in reasonable agreement. Small changes in tge molecular parameters of the individual glycosphingolipids or in their proportion in mixtures with dipalmitoylphosphatidylcholine bring about remarkable variations on the type of structure formed, its radius of curvature and thermodynamic stability.",
keywords = "Dipalmitoylphosphatidylcholine, Ganglioside, Geometrics, Glycosphingolipid, Membrane morphology, Thermodynamics",
author = "Bruno Maggio and John Albert and Yu, {Robert K.}",
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AU - Maggio, Bruno

AU - Albert, John

AU - Yu, Robert K.

PY - 1988/11/22

Y1 - 1988/11/22

N2 - The morphology of aqueous dispersions of five neutral glycosphingolipids (GalCer, GlcCer, LacCer, asialo-GM2, asialo-GM1), sulfatide, and five gangliosides (GM3, GM2, GM1, GD1a and Gt1b) and their mixtures with dipalmitoylphosphatidylcholine was studied by negative staining electron microscopy. The morphological features are interpreted on the basis of thermodynamic and geometric constraints previously studied in these systems (Maggio, B (1985) Biochim. Biophys. Acta 815, 245-258). The correlation between the theoretical predictions and the experimental findings are in reasonable agreement. Small changes in tge molecular parameters of the individual glycosphingolipids or in their proportion in mixtures with dipalmitoylphosphatidylcholine bring about remarkable variations on the type of structure formed, its radius of curvature and thermodynamic stability.

AB - The morphology of aqueous dispersions of five neutral glycosphingolipids (GalCer, GlcCer, LacCer, asialo-GM2, asialo-GM1), sulfatide, and five gangliosides (GM3, GM2, GM1, GD1a and Gt1b) and their mixtures with dipalmitoylphosphatidylcholine was studied by negative staining electron microscopy. The morphological features are interpreted on the basis of thermodynamic and geometric constraints previously studied in these systems (Maggio, B (1985) Biochim. Biophys. Acta 815, 245-258). The correlation between the theoretical predictions and the experimental findings are in reasonable agreement. Small changes in tge molecular parameters of the individual glycosphingolipids or in their proportion in mixtures with dipalmitoylphosphatidylcholine bring about remarkable variations on the type of structure formed, its radius of curvature and thermodynamic stability.

KW - Dipalmitoylphosphatidylcholine

KW - Ganglioside

KW - Geometrics

KW - Glycosphingolipid

KW - Membrane morphology

KW - Thermodynamics

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