Thermodynamic-geometric correlations for the morphology of self-assembled structures of glycosphingolipids and their mixtures with dipalmitoylphosphatidylcholine

Bruno Maggio, John Albert, Robert K. Yu

Research output: Contribution to journalArticle

61 Scopus citations


The morphology of aqueous dispersions of five neutral glycosphingolipids (GalCer, GlcCer, LacCer, asialo-GM2, asialo-GM1), sulfatide, and five gangliosides (GM3, GM2, GM1, GD1a and Gt1b) and their mixtures with dipalmitoylphosphatidylcholine was studied by negative staining electron microscopy. The morphological features are interpreted on the basis of thermodynamic and geometric constraints previously studied in these systems (Maggio, B (1985) Biochim. Biophys. Acta 815, 245-258). The correlation between the theoretical predictions and the experimental findings are in reasonable agreement. Small changes in tge molecular parameters of the individual glycosphingolipids or in their proportion in mixtures with dipalmitoylphosphatidylcholine bring about remarkable variations on the type of structure formed, its radius of curvature and thermodynamic stability.

Original languageEnglish (US)
Pages (from-to)145-160
Number of pages16
JournalBBA - Biomembranes
Issue number2
Publication statusPublished - Nov 22 1988
Externally publishedYes



  • Dipalmitoylphosphatidylcholine
  • Ganglioside
  • Geometrics
  • Glycosphingolipid
  • Membrane morphology
  • Thermodynamics

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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