Thermoregulatory responses following injection of 5-hydroxytryptamine into the septohippocampal complex in rats

Y. Cui, T. F. Lee, L. C.H. Wang

Research output: Contribution to journalArticle

15 Scopus citations


The present study investigated the change in thermoregulatory responses following microinjection of 5-hydroxytryptamine (5-HT) into the lateral septum and the hippocampus of unanesthetized, unrestrained rats. Intraseptal injection of 5-HT (5 to 20 μg) caused a dose-related fall in core temperature (Tb), which was associated with a decrease in heat production (HP). As the decrease in HP can not completely account for the magnitude of the decrease in Tb, increase in heat loss may also be involved in the 5-HT-induced hypothermia. In contrast to observed changes following intraseptal injection, no significant change in either Tb or HP was observed after microinjection of the same doses of 5-HT into the hippocampal areas, indicating that the hypothermic response to intraseptal injection of 5-HT is site specific. Further, the hypothermic response to intraseptal injection of 5-HT was only attenuated by systemic pretreatment with cyproheptadine, but not by naloxone or scopolamine, indicating that the hypothermic response is mediated by 5-HT receptor, but not by endogenous opioid and cholinergic systems.

Original languageEnglish (US)
Pages (from-to)935-939
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Issue number4
Publication statusPublished - Aug 1993
Externally publishedYes



  • 5-Hydroxytryptamine
  • Heat production
  • Hippocampus
  • Hypothermia
  • Lateral septum
  • Thermoregulation

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this