Thermoregulatory responses following injection of 5-hydroxytryptamine into the septohippocampal complex in rats

Y. Cui, T. F. Lee, L. C.H. Wang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The present study investigated the change in thermoregulatory responses following microinjection of 5-hydroxytryptamine (5-HT) into the lateral septum and the hippocampus of unanesthetized, unrestrained rats. Intraseptal injection of 5-HT (5 to 20 μg) caused a dose-related fall in core temperature (Tb), which was associated with a decrease in heat production (HP). As the decrease in HP can not completely account for the magnitude of the decrease in Tb, increase in heat loss may also be involved in the 5-HT-induced hypothermia. In contrast to observed changes following intraseptal injection, no significant change in either Tb or HP was observed after microinjection of the same doses of 5-HT into the hippocampal areas, indicating that the hypothermic response to intraseptal injection of 5-HT is site specific. Further, the hypothermic response to intraseptal injection of 5-HT was only attenuated by systemic pretreatment with cyproheptadine, but not by naloxone or scopolamine, indicating that the hypothermic response is mediated by 5-HT receptor, but not by endogenous opioid and cholinergic systems.

Original languageEnglish (US)
Pages (from-to)935-939
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume45
Issue number4
DOIs
StatePublished - Aug 1993

Fingerprint

Rats
Serotonin
Injections
Thermogenesis
Microinjections
Hypothermia
Cyproheptadine
Induced Hypothermia
Scopolamine Hydrobromide
Serotonin Receptors
Naloxone
Heat losses
Cholinergic Agents
Opioid Analgesics
Hippocampus
Hot Temperature
Temperature

Keywords

  • 5-Hydroxytryptamine
  • Heat production
  • Hippocampus
  • Hypothermia
  • Lateral septum
  • Thermoregulation

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Thermoregulatory responses following injection of 5-hydroxytryptamine into the septohippocampal complex in rats. / Cui, Y.; Lee, T. F.; Wang, L. C.H.

In: Pharmacology, Biochemistry and Behavior, Vol. 45, No. 4, 08.1993, p. 935-939.

Research output: Contribution to journalArticle

@article{304756f087084e38a3eba295ab73ccd1,
title = "Thermoregulatory responses following injection of 5-hydroxytryptamine into the septohippocampal complex in rats",
abstract = "The present study investigated the change in thermoregulatory responses following microinjection of 5-hydroxytryptamine (5-HT) into the lateral septum and the hippocampus of unanesthetized, unrestrained rats. Intraseptal injection of 5-HT (5 to 20 μg) caused a dose-related fall in core temperature (Tb), which was associated with a decrease in heat production (HP). As the decrease in HP can not completely account for the magnitude of the decrease in Tb, increase in heat loss may also be involved in the 5-HT-induced hypothermia. In contrast to observed changes following intraseptal injection, no significant change in either Tb or HP was observed after microinjection of the same doses of 5-HT into the hippocampal areas, indicating that the hypothermic response to intraseptal injection of 5-HT is site specific. Further, the hypothermic response to intraseptal injection of 5-HT was only attenuated by systemic pretreatment with cyproheptadine, but not by naloxone or scopolamine, indicating that the hypothermic response is mediated by 5-HT receptor, but not by endogenous opioid and cholinergic systems.",
keywords = "5-Hydroxytryptamine, Heat production, Hippocampus, Hypothermia, Lateral septum, Thermoregulation",
author = "Y. Cui and Lee, {T. F.} and Wang, {L. C.H.}",
year = "1993",
month = "8",
doi = "10.1016/0091-3057(93)90143-H",
language = "English (US)",
volume = "45",
pages = "935--939",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Thermoregulatory responses following injection of 5-hydroxytryptamine into the septohippocampal complex in rats

AU - Cui, Y.

AU - Lee, T. F.

AU - Wang, L. C.H.

PY - 1993/8

Y1 - 1993/8

N2 - The present study investigated the change in thermoregulatory responses following microinjection of 5-hydroxytryptamine (5-HT) into the lateral septum and the hippocampus of unanesthetized, unrestrained rats. Intraseptal injection of 5-HT (5 to 20 μg) caused a dose-related fall in core temperature (Tb), which was associated with a decrease in heat production (HP). As the decrease in HP can not completely account for the magnitude of the decrease in Tb, increase in heat loss may also be involved in the 5-HT-induced hypothermia. In contrast to observed changes following intraseptal injection, no significant change in either Tb or HP was observed after microinjection of the same doses of 5-HT into the hippocampal areas, indicating that the hypothermic response to intraseptal injection of 5-HT is site specific. Further, the hypothermic response to intraseptal injection of 5-HT was only attenuated by systemic pretreatment with cyproheptadine, but not by naloxone or scopolamine, indicating that the hypothermic response is mediated by 5-HT receptor, but not by endogenous opioid and cholinergic systems.

AB - The present study investigated the change in thermoregulatory responses following microinjection of 5-hydroxytryptamine (5-HT) into the lateral septum and the hippocampus of unanesthetized, unrestrained rats. Intraseptal injection of 5-HT (5 to 20 μg) caused a dose-related fall in core temperature (Tb), which was associated with a decrease in heat production (HP). As the decrease in HP can not completely account for the magnitude of the decrease in Tb, increase in heat loss may also be involved in the 5-HT-induced hypothermia. In contrast to observed changes following intraseptal injection, no significant change in either Tb or HP was observed after microinjection of the same doses of 5-HT into the hippocampal areas, indicating that the hypothermic response to intraseptal injection of 5-HT is site specific. Further, the hypothermic response to intraseptal injection of 5-HT was only attenuated by systemic pretreatment with cyproheptadine, but not by naloxone or scopolamine, indicating that the hypothermic response is mediated by 5-HT receptor, but not by endogenous opioid and cholinergic systems.

KW - 5-Hydroxytryptamine

KW - Heat production

KW - Hippocampus

KW - Hypothermia

KW - Lateral septum

KW - Thermoregulation

UR - http://www.scopus.com/inward/record.url?scp=0027202737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027202737&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(93)90143-H

DO - 10.1016/0091-3057(93)90143-H

M3 - Article

C2 - 8415834

AN - SCOPUS:0027202737

VL - 45

SP - 935

EP - 939

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 4

ER -