Thirty-seven candidate genes for polycystic ovary syndrome

Strongest evidence for linkage is with follistatin

Margrit Urbanek, Richard S. Legro, Deborah A. Driscoll, Ricardo Azziz, David A. Ehrmann, Robert J. Norman, Jerome F. Strauss, Richard S. Spielman, Andrea Dunaif

Research output: Contribution to journalArticle

386 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder of women, characterized by hyperandrogenism and chronic anovulation. It is a leading cause of female infertility and is associated with polycystic ovaries, hirsutism, obesity, and insulin resistance. We tested a carefully chosen collection of 37 candidate genes for linkage and association with PCOS or hyperandrogenemia in data from 150 families. The strongest evidence for linkage was with the follistatin gene, for which affected sisters showed increased identity by descent (72%; χ2 = 12.97; nominal P = 3.2 x 10-4). After correction for multiple testing (33 tests), the follistatin findings were still highly significant (P(c) = 0.01). Although the linkage results for CYP11A were also nominally significant (P = 0.02), they were no longer significant after correction. In 11 candidate gene regions, at least one allele showed nominally significant evidence for population association with PCOS in the transmission/disequilibrium test (χ2 ≥ 3.84; nominal P < 0.05). The strongest effect in the transmission/disequilibrium test was observed in the INSR region (D19S884; allele 5; χ2 = 8.53) but was not significant after correction. Our study shows how a systematic screen of candidate genes can provide strong evidence for genetic linkage in complex diseases and can identify those genes that should have high (or low) priority for further study.

Original languageEnglish (US)
Pages (from-to)8573-8578
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue number15
DOIs
StatePublished - Jul 20 1999

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Follistatin
Polycystic Ovary Syndrome
Genes
Alleles
Anovulation
Female Infertility
Hyperandrogenism
Hirsutism
Genetic Linkage
Insulin Resistance
Siblings
Ovary
Obesity
Population

ASJC Scopus subject areas

  • General

Cite this

Thirty-seven candidate genes for polycystic ovary syndrome : Strongest evidence for linkage is with follistatin. / Urbanek, Margrit; Legro, Richard S.; Driscoll, Deborah A.; Azziz, Ricardo; Ehrmann, David A.; Norman, Robert J.; Strauss, Jerome F.; Spielman, Richard S.; Dunaif, Andrea.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 15, 20.07.1999, p. 8573-8578.

Research output: Contribution to journalArticle

Urbanek, M, Legro, RS, Driscoll, DA, Azziz, R, Ehrmann, DA, Norman, RJ, Strauss, JF, Spielman, RS & Dunaif, A 1999, 'Thirty-seven candidate genes for polycystic ovary syndrome: Strongest evidence for linkage is with follistatin', Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 15, pp. 8573-8578. https://doi.org/10.1073/pnas.96.15.8573
Urbanek, Margrit ; Legro, Richard S. ; Driscoll, Deborah A. ; Azziz, Ricardo ; Ehrmann, David A. ; Norman, Robert J. ; Strauss, Jerome F. ; Spielman, Richard S. ; Dunaif, Andrea. / Thirty-seven candidate genes for polycystic ovary syndrome : Strongest evidence for linkage is with follistatin. In: Proceedings of the National Academy of Sciences of the United States of America. 1999 ; Vol. 96, No. 15. pp. 8573-8578.
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