Three dimensional MR-based morphometric comparison of schizophrenic and normal cerebral ventricles

David Dean, Peter Buckley, Fred Bookstein, Janardhan Kamath, David Kwon, Lee Friedman, Christine Lys

Research output: Chapter in Book/Report/Conference proceedingConference contribution

27 Scopus citations

Abstract

Enlarged cerebral ventricles are consistently detected in patients suffering from schizophrenia. Several workers report more detailed association of this disease and particular brain areas, hi order to assist these efforts at localization we define a tiled-out map of the ventricular surface, a template, based on specialized crest lines that we term: ridge curves. In this analysis we use this template to (1) average 3D MR-based ventricular surface images collected from 12 patients and 12 controls, and (2) locate the position of regularly occurring curvature maxima landmarks along the ridge curves. Statistical analysis of the locations of these curvature maxima landmarks indicate promising localization of a shape difference associated with schizophrenia in the frontal horn of the lateral cerebral ventricle.

Original languageEnglish (US)
Title of host publicationVisualization in Biomedical Computing - 4th International Conference, VBC 1996, Proceedings
EditorsRon Kikinis, Karl Heinz Hohne
PublisherSpringer Verlag
Pages362-372
Number of pages11
ISBN (Print)3540616497, 9783540616498
Publication statusPublished - Jan 1 1996
Event4th International Conference on Visualization in Biomedical Computing, VBC 1996 - Hamburg, Germany
Duration: Sep 22 1996Sep 25 1996

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume1131
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other4th International Conference on Visualization in Biomedical Computing, VBC 1996
CountryGermany
CityHamburg
Period9/22/969/25/96

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ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Cite this

Dean, D., Buckley, P., Bookstein, F., Kamath, J., Kwon, D., Friedman, L., & Lys, C. (1996). Three dimensional MR-based morphometric comparison of schizophrenic and normal cerebral ventricles. In R. Kikinis, & K. H. Hohne (Eds.), Visualization in Biomedical Computing - 4th International Conference, VBC 1996, Proceedings (pp. 362-372). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 1131). Springer Verlag.