Three dimensional MR-based morphometric comparison of schizophrenic and normal cerebral ventricles

David Dean, Peter Buckley, Fred Bookstein, Janardhan Kamath, David Kwon, Lee Friedman, Christine Lys

Research output: Chapter in Book/Report/Conference proceedingConference contribution

27 Citations (Scopus)

Abstract

Enlarged cerebral ventricles are consistently detected in patients suffering from schizophrenia. Several workers report more detailed association of this disease and particular brain areas, hi order to assist these efforts at localization we define a tiled-out map of the ventricular surface, a template, based on specialized crest lines that we term: ridge curves. In this analysis we use this template to (1) average 3D MR-based ventricular surface images collected from 12 patients and 12 controls, and (2) locate the position of regularly occurring curvature maxima landmarks along the ridge curves. Statistical analysis of the locations of these curvature maxima landmarks indicate promising localization of a shape difference associated with schizophrenia in the frontal horn of the lateral cerebral ventricle.

Original languageEnglish (US)
Title of host publicationVisualization in Biomedical Computing - 4th International Conference, VBC 1996, Proceedings
EditorsRon Kikinis, Karl Heinz Hohne
PublisherSpringer Verlag
Pages362-372
Number of pages11
ISBN (Print)3540616497, 9783540616498
StatePublished - Jan 1 1996
Event4th International Conference on Visualization in Biomedical Computing, VBC 1996 - Hamburg, Germany
Duration: Sep 22 1996Sep 25 1996

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume1131
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other4th International Conference on Visualization in Biomedical Computing, VBC 1996
CountryGermany
CityHamburg
Period9/22/969/25/96

Fingerprint

Ridge
Landmarks
Template
Curvature
Three-dimensional
Curve
Statistical Analysis
Lateral
Brain
Statistical methods
Line
Term

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Cite this

Dean, D., Buckley, P., Bookstein, F., Kamath, J., Kwon, D., Friedman, L., & Lys, C. (1996). Three dimensional MR-based morphometric comparison of schizophrenic and normal cerebral ventricles. In R. Kikinis, & K. H. Hohne (Eds.), Visualization in Biomedical Computing - 4th International Conference, VBC 1996, Proceedings (pp. 362-372). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 1131). Springer Verlag.

Three dimensional MR-based morphometric comparison of schizophrenic and normal cerebral ventricles. / Dean, David; Buckley, Peter; Bookstein, Fred; Kamath, Janardhan; Kwon, David; Friedman, Lee; Lys, Christine.

Visualization in Biomedical Computing - 4th International Conference, VBC 1996, Proceedings. ed. / Ron Kikinis; Karl Heinz Hohne. Springer Verlag, 1996. p. 362-372 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 1131).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dean, D, Buckley, P, Bookstein, F, Kamath, J, Kwon, D, Friedman, L & Lys, C 1996, Three dimensional MR-based morphometric comparison of schizophrenic and normal cerebral ventricles. in R Kikinis & KH Hohne (eds), Visualization in Biomedical Computing - 4th International Conference, VBC 1996, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 1131, Springer Verlag, pp. 362-372, 4th International Conference on Visualization in Biomedical Computing, VBC 1996, Hamburg, Germany, 9/22/96.
Dean D, Buckley P, Bookstein F, Kamath J, Kwon D, Friedman L et al. Three dimensional MR-based morphometric comparison of schizophrenic and normal cerebral ventricles. In Kikinis R, Hohne KH, editors, Visualization in Biomedical Computing - 4th International Conference, VBC 1996, Proceedings. Springer Verlag. 1996. p. 362-372. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
Dean, David ; Buckley, Peter ; Bookstein, Fred ; Kamath, Janardhan ; Kwon, David ; Friedman, Lee ; Lys, Christine. / Three dimensional MR-based morphometric comparison of schizophrenic and normal cerebral ventricles. Visualization in Biomedical Computing - 4th International Conference, VBC 1996, Proceedings. editor / Ron Kikinis ; Karl Heinz Hohne. Springer Verlag, 1996. pp. 362-372 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
@inproceedings{8017612e304b47fbbe94586da276d7a3,
title = "Three dimensional MR-based morphometric comparison of schizophrenic and normal cerebral ventricles",
abstract = "Enlarged cerebral ventricles are consistently detected in patients suffering from schizophrenia. Several workers report more detailed association of this disease and particular brain areas, hi order to assist these efforts at localization we define a tiled-out map of the ventricular surface, a template, based on specialized crest lines that we term: ridge curves. In this analysis we use this template to (1) average 3D MR-based ventricular surface images collected from 12 patients and 12 controls, and (2) locate the position of regularly occurring curvature maxima landmarks along the ridge curves. Statistical analysis of the locations of these curvature maxima landmarks indicate promising localization of a shape difference associated with schizophrenia in the frontal horn of the lateral cerebral ventricle.",
author = "David Dean and Peter Buckley and Fred Bookstein and Janardhan Kamath and David Kwon and Lee Friedman and Christine Lys",
year = "1996",
month = "1",
day = "1",
language = "English (US)",
isbn = "3540616497",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "362--372",
editor = "Ron Kikinis and Hohne, {Karl Heinz}",
booktitle = "Visualization in Biomedical Computing - 4th International Conference, VBC 1996, Proceedings",

}

TY - GEN

T1 - Three dimensional MR-based morphometric comparison of schizophrenic and normal cerebral ventricles

AU - Dean, David

AU - Buckley, Peter

AU - Bookstein, Fred

AU - Kamath, Janardhan

AU - Kwon, David

AU - Friedman, Lee

AU - Lys, Christine

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Enlarged cerebral ventricles are consistently detected in patients suffering from schizophrenia. Several workers report more detailed association of this disease and particular brain areas, hi order to assist these efforts at localization we define a tiled-out map of the ventricular surface, a template, based on specialized crest lines that we term: ridge curves. In this analysis we use this template to (1) average 3D MR-based ventricular surface images collected from 12 patients and 12 controls, and (2) locate the position of regularly occurring curvature maxima landmarks along the ridge curves. Statistical analysis of the locations of these curvature maxima landmarks indicate promising localization of a shape difference associated with schizophrenia in the frontal horn of the lateral cerebral ventricle.

AB - Enlarged cerebral ventricles are consistently detected in patients suffering from schizophrenia. Several workers report more detailed association of this disease and particular brain areas, hi order to assist these efforts at localization we define a tiled-out map of the ventricular surface, a template, based on specialized crest lines that we term: ridge curves. In this analysis we use this template to (1) average 3D MR-based ventricular surface images collected from 12 patients and 12 controls, and (2) locate the position of regularly occurring curvature maxima landmarks along the ridge curves. Statistical analysis of the locations of these curvature maxima landmarks indicate promising localization of a shape difference associated with schizophrenia in the frontal horn of the lateral cerebral ventricle.

UR - http://www.scopus.com/inward/record.url?scp=84947729321&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947729321&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84947729321

SN - 3540616497

SN - 9783540616498

T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

SP - 362

EP - 372

BT - Visualization in Biomedical Computing - 4th International Conference, VBC 1996, Proceedings

A2 - Kikinis, Ron

A2 - Hohne, Karl Heinz

PB - Springer Verlag

ER -