Thrombospondin-1 and its CSVTCG-specific receptor in wound healing and cancer

Jeffrey J. Roth, Daniel Albo, Vicki L. Rothman, Michael T. Longaker, Mark S. Granick, Charles D. Long, Mark P. Solomon, George P. Tuszynski

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Growth factors play a crucial role in the regulation of cellular proliferation and matrix degradation in wound healing and cancer. We have shown that thrombospondin 1 (TSP-1) and its cysteine-serine-valine-threonine- cysteine-glycine (CSVTCG)-specific receptor play a key role in cell invasion and matrix degradation in different carcinomas. The present study was done to determine whether TSP-1 and its receptor show a similar pattern of expression in wound healing and cancer. Expression and localization of TSP-1 and its receptor were determined in fetal wounds, adult burn wounds, and different human malignancies by immunohistochemical staining and computerized image analysis. In healing wounds, TSP-1 was expressed in the stroma early in the process, followed by a steep decline. The TSP-1 receptor localized to neovessels and highly proliferating cells (i.e., fibroblasts, basal cells), its levels remaining relatively constant. Cancer cells and tumor-associated microvessels expressed the TSP-1 receptor, whereas TSP-1 localized predominantly to the tumor-associated stroma. These data suggest a critical role for TSP-1 and its CSVTCG-specific receptor in wound healing and cancer.

Original languageEnglish (US)
Pages (from-to)494-501
Number of pages8
JournalAnnals of Plastic Surgery
Volume40
Issue number5
DOIs
StatePublished - May 25 1998
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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    Roth, J. J., Albo, D., Rothman, V. L., Longaker, M. T., Granick, M. S., Long, C. D., Solomon, M. P., & Tuszynski, G. P. (1998). Thrombospondin-1 and its CSVTCG-specific receptor in wound healing and cancer. Annals of Plastic Surgery, 40(5), 494-501. https://doi.org/10.1097/00000637-199805000-00009