Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population

Xiaoyang Zhou, Jianfeng Huang, Jianhong Chen, Jiangong Zhao, Wenjie Yang, Xiaoling Wang, Dongfeng Gu

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Recently, conflicting data have been reported regarding the possible contribution of the TSP-4 (thrombospondin-4) A387P polymorphism to CAD (coronary artery disease) or MI (myocardial infarction). To investigate a possible association between the A387P polymorphism and CAD or MI in the Chinese Man population, we conducted a case-controlled study including 817 patients with angiographicalty verified CAD or those who survived an acute MI and 847 control subjects. The TSP-4 A387P polymorphism was determined by PCR and PCR-RFLP (restriction-fragment-length polymorphism) analysis. The prevalence of the 387P allele was 3.8% in the healthy controls, which was less frequent than those in Western populations (19.6-23.2%). No association of the A387P polymorphism with an altered risk of CAD, MI or premature MI was found in our present study (CG + CC compared with GG, PCAD = 0.51, PMI = 0.13, P PrematureMI = 0.17 respectively). We concluded that a relationship between the TSP-4 A387P polymorphism and CAD or MI was unlikely in our population. Additional investigations should be performed in populations at different risk of coronary events in order to elucidate further the possible contribution of this polymorphism to cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)495-500
Number of pages6
JournalClinical Science
Volume106
Issue number5
DOIs
StatePublished - May 1 2004
Externally publishedYes

Keywords

  • Association study
  • Coronary artery disease
  • Myocardial infarction
  • Polymorphism
  • Thrombospondin

ASJC Scopus subject areas

  • Medicine(all)

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