Through the looking glass: Basics and principles of reflectance confocal microscopy

Syril Keena T. Que; Naiara Fraga-Braghiroli; Jane M. Grant-Kels; Harold S. Rabinovitz; Margaret Oliviero; Alon Scope

doi:10.1016/j.jaad.2015.04.047

Through the looking glass: Basics and principles of reflectance confocal microscopy

Syril Keena T. Que, Naiara Fraga-Braghiroli, Jane M. Grant-Kels, Harold S. Rabinovitz, Margaret Oliviero, Alon Scope

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

Reflectance confocal microscopy (RCM) offers high-resolution, noninvasive skin imaging and can help avoid obtaining unnecessary biopsy specimens. It can also increase efficiency in the surgical setting by helping to delineate tumor margins. Diagnostic criteria and several RCM algorithms have been published for the differentiation of benign and malignant neoplasms. We provide an overview of the basic principles of RCM, characteristic RCM features of normal skin and cutaneous neoplasms, and the limitations and future directions of RCM.

Original language	English (US)
Pages (from-to)	276-284
Number of pages	9
Journal	Journal of the American Academy of Dermatology
Volume	73
Issue number	2
DOIs	https://doi.org/10.1016/j.jaad.2015.04.047
State	Published - Aug 1 2015
Externally published	Yes

Keywords

basal cell carcinoma
cutaneous oncology
melanoma
noninvasive imaging
reflectance confocal microscopy
squamous cell carcinoma
tumors/neoplasm

ASJC Scopus subject areas

Dermatology

Access to Document

10.1016/j.jaad.2015.04.047

Cite this

@article{563a129a827a4e1794ceebfe9dd4c55a,

title = "Through the looking glass: Basics and principles of reflectance confocal microscopy",

abstract = "Reflectance confocal microscopy (RCM) offers high-resolution, noninvasive skin imaging and can help avoid obtaining unnecessary biopsy specimens. It can also increase efficiency in the surgical setting by helping to delineate tumor margins. Diagnostic criteria and several RCM algorithms have been published for the differentiation of benign and malignant neoplasms. We provide an overview of the basic principles of RCM, characteristic RCM features of normal skin and cutaneous neoplasms, and the limitations and future directions of RCM.",

keywords = "basal cell carcinoma, cutaneous oncology, melanoma, noninvasive imaging, reflectance confocal microscopy, squamous cell carcinoma, tumors/neoplasm",

author = "Que, {Syril Keena T.} and Naiara Fraga-Braghiroli and Grant-Kels, {Jane M.} and Rabinovitz, {Harold S.} and Margaret Oliviero and Alon Scope",

note = "Funding Information: Supported by the European Commission Marie Curie FP7 Reintegration Grant to Dr Scope ( PIRG07-GA-2010-268359 ). Dr Rabinovitz has received equipment and funding for a fellowship program from Lucid Inc. Publisher Copyright: {\textcopyright} 2015 American Academy of Dermatology, Inc.",

year = "2015",

month = aug,

day = "1",

doi = "10.1016/j.jaad.2015.04.047",

language = "English (US)",

volume = "73",

pages = "276--284",

journal = "Journal of the American Academy of Dermatology",

issn = "0190-9622",

publisher = "Mosby Inc.",

number = "2",

}

TY - JOUR

T1 - Through the looking glass

T2 - Basics and principles of reflectance confocal microscopy

AU - Que, Syril Keena T.

AU - Fraga-Braghiroli, Naiara

AU - Grant-Kels, Jane M.

AU - Rabinovitz, Harold S.

AU - Oliviero, Margaret

AU - Scope, Alon

N1 - Funding Information: Supported by the European Commission Marie Curie FP7 Reintegration Grant to Dr Scope ( PIRG07-GA-2010-268359 ). Dr Rabinovitz has received equipment and funding for a fellowship program from Lucid Inc. Publisher Copyright: © 2015 American Academy of Dermatology, Inc.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Reflectance confocal microscopy (RCM) offers high-resolution, noninvasive skin imaging and can help avoid obtaining unnecessary biopsy specimens. It can also increase efficiency in the surgical setting by helping to delineate tumor margins. Diagnostic criteria and several RCM algorithms have been published for the differentiation of benign and malignant neoplasms. We provide an overview of the basic principles of RCM, characteristic RCM features of normal skin and cutaneous neoplasms, and the limitations and future directions of RCM.

AB - Reflectance confocal microscopy (RCM) offers high-resolution, noninvasive skin imaging and can help avoid obtaining unnecessary biopsy specimens. It can also increase efficiency in the surgical setting by helping to delineate tumor margins. Diagnostic criteria and several RCM algorithms have been published for the differentiation of benign and malignant neoplasms. We provide an overview of the basic principles of RCM, characteristic RCM features of normal skin and cutaneous neoplasms, and the limitations and future directions of RCM.

KW - basal cell carcinoma

KW - cutaneous oncology

KW - melanoma

KW - noninvasive imaging

KW - reflectance confocal microscopy

KW - squamous cell carcinoma

KW - tumors/neoplasm

UR - http://www.scopus.com/inward/record.url?scp=84937513436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937513436&partnerID=8YFLogxK

U2 - 10.1016/j.jaad.2015.04.047

DO - 10.1016/j.jaad.2015.04.047

M3 - Review article

C2 - 26051696

AN - SCOPUS:84937513436

SN - 0190-9622

VL - 73

SP - 276

EP - 284

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 2

ER -

Through the looking glass: Basics and principles of reflectance confocal microscopy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this