The audiogenic seizure (AS) susceptibility of DBA 2J (D2) mice could be suppressed by administration of the antithyroid drug 6-n-propyl-2-thiouracil from 3 days before birth until the time of AS testing (19 days after birth). This treatment effectively induced hypothyroidism. The AS susceptibility of these mice, however, could be almost completely restored by thyroxine replacement from postnatal day 1 through postnatal day 17. The restoration of AS susceptibility by thyroxine replacement was not accompanied by a corresponding restoration of normal serum thyroxine and estimated free thyroxine levels. These observations suggest that thyroid hormone may influence AS susceptibility at some early critical stage of brain development and may be an important requirement for the development of AS susceptibility in D2 mice.
ASJC Scopus subject areas