Thyroid hormone can restore the audiogenic seizure susceptibility of hypothyroid DBA 2J mice

Thomas N. Seyfried, Gilbert H. Glaser, Robert K Yu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The audiogenic seizure (AS) susceptibility of DBA 2J (D2) mice could be suppressed by administration of the antithyroid drug 6-n-propyl-2-thiouracil from 3 days before birth until the time of AS testing (19 days after birth). This treatment effectively induced hypothyroidism. The AS susceptibility of these mice, however, could be almost completely restored by thyroxine replacement from postnatal day 1 through postnatal day 17. The restoration of AS susceptibility by thyroxine replacement was not accompanied by a corresponding restoration of normal serum thyroxine and estimated free thyroxine levels. These observations suggest that thyroid hormone may influence AS susceptibility at some early critical stage of brain development and may be an important requirement for the development of AS susceptibility in D2 mice.

Original languageEnglish (US)
Pages (from-to)220-225
Number of pages6
JournalExperimental Neurology
Volume71
Issue number1
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

Fingerprint

Inbred DBA Mouse
Thyroid Hormones
Seizures
Thyroxine
Parturition
Antithyroid Agents
Propylthiouracil
Hypothyroidism
Brain
Serum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Thyroid hormone can restore the audiogenic seizure susceptibility of hypothyroid DBA 2J mice. / Seyfried, Thomas N.; Glaser, Gilbert H.; Yu, Robert K.

In: Experimental Neurology, Vol. 71, No. 1, 01.01.1981, p. 220-225.

Research output: Contribution to journalArticle

Seyfried, Thomas N. ; Glaser, Gilbert H. ; Yu, Robert K. / Thyroid hormone can restore the audiogenic seizure susceptibility of hypothyroid DBA 2J mice. In: Experimental Neurology. 1981 ; Vol. 71, No. 1. pp. 220-225.
@article{3e182acd7f104734a5b139a3b09bd4ac,
title = "Thyroid hormone can restore the audiogenic seizure susceptibility of hypothyroid DBA 2J mice",
abstract = "The audiogenic seizure (AS) susceptibility of DBA 2J (D2) mice could be suppressed by administration of the antithyroid drug 6-n-propyl-2-thiouracil from 3 days before birth until the time of AS testing (19 days after birth). This treatment effectively induced hypothyroidism. The AS susceptibility of these mice, however, could be almost completely restored by thyroxine replacement from postnatal day 1 through postnatal day 17. The restoration of AS susceptibility by thyroxine replacement was not accompanied by a corresponding restoration of normal serum thyroxine and estimated free thyroxine levels. These observations suggest that thyroid hormone may influence AS susceptibility at some early critical stage of brain development and may be an important requirement for the development of AS susceptibility in D2 mice.",
author = "Seyfried, {Thomas N.} and Glaser, {Gilbert H.} and Yu, {Robert K}",
year = "1981",
month = "1",
day = "1",
doi = "10.1016/0014-4886(81)90083-2",
language = "English (US)",
volume = "71",
pages = "220--225",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Thyroid hormone can restore the audiogenic seizure susceptibility of hypothyroid DBA 2J mice

AU - Seyfried, Thomas N.

AU - Glaser, Gilbert H.

AU - Yu, Robert K

PY - 1981/1/1

Y1 - 1981/1/1

N2 - The audiogenic seizure (AS) susceptibility of DBA 2J (D2) mice could be suppressed by administration of the antithyroid drug 6-n-propyl-2-thiouracil from 3 days before birth until the time of AS testing (19 days after birth). This treatment effectively induced hypothyroidism. The AS susceptibility of these mice, however, could be almost completely restored by thyroxine replacement from postnatal day 1 through postnatal day 17. The restoration of AS susceptibility by thyroxine replacement was not accompanied by a corresponding restoration of normal serum thyroxine and estimated free thyroxine levels. These observations suggest that thyroid hormone may influence AS susceptibility at some early critical stage of brain development and may be an important requirement for the development of AS susceptibility in D2 mice.

AB - The audiogenic seizure (AS) susceptibility of DBA 2J (D2) mice could be suppressed by administration of the antithyroid drug 6-n-propyl-2-thiouracil from 3 days before birth until the time of AS testing (19 days after birth). This treatment effectively induced hypothyroidism. The AS susceptibility of these mice, however, could be almost completely restored by thyroxine replacement from postnatal day 1 through postnatal day 17. The restoration of AS susceptibility by thyroxine replacement was not accompanied by a corresponding restoration of normal serum thyroxine and estimated free thyroxine levels. These observations suggest that thyroid hormone may influence AS susceptibility at some early critical stage of brain development and may be an important requirement for the development of AS susceptibility in D2 mice.

UR - http://www.scopus.com/inward/record.url?scp=0019378890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019378890&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(81)90083-2

DO - 10.1016/0014-4886(81)90083-2

M3 - Article

C2 - 6161026

AN - SCOPUS:0019378890

VL - 71

SP - 220

EP - 225

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 1

ER -