Time course of short-term and long-term orexigenic effects of Agouti-related protein (86-132)

X. Y. Lu; J. R. Nicholson; H. Akil; S. J. Watson

doi:10.1097/00001756-200105080-00045

Time course of short-term and long-term orexigenic effects of Agouti-related protein (86-132)

X. Y. Lu, J. R. Nicholson, H. Akil, S. J. Watson

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Agouti-related protein (AGRP) is a newly identified orexigenic peptide that acts as an endogenous antagonist of melanocortin receptors MC3 and MC4. The present study examined the time course of the orexigenic effects of synthetic AGRP (86-132). Intracerebroventricular infusion of 0.1 nmol AGRP (86-132) increased food intake by 450 ± 81% at 2h post-injection. A second increase in non-cumulative food intake (512 ± 135%) was observed at 6h post-injection. Following a single dose of AGRP (86-132) (0.1 nmol) the increased food intake was sustained for 6 days, occurring in the light cycle of the first 2 days and subsequently switching to the dark cycle of the last 4 days. These time course profiles indicate the complexity of the mechanisms involved in AGRP-induced feeding.

Original language	English (US)
Pages (from-to)	1281-1284
Number of pages	4
Journal	NeuroReport
Volume	12
Issue number	6
DOIs	https://doi.org/10.1097/00001756-200105080-00045
State	Published - May 8 2001
Externally published	Yes

Keywords

Agouti-related protein (AGRP)
Dark cycle
Food intake
Light cycle

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-200105080-00045

Cite this

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title = "Time course of short-term and long-term orexigenic effects of Agouti-related protein (86-132)",

abstract = "Agouti-related protein (AGRP) is a newly identified orexigenic peptide that acts as an endogenous antagonist of melanocortin receptors MC3 and MC4. The present study examined the time course of the orexigenic effects of synthetic AGRP (86-132). Intracerebroventricular infusion of 0.1 nmol AGRP (86-132) increased food intake by 450 ± 81% at 2h post-injection. A second increase in non-cumulative food intake (512 ± 135%) was observed at 6h post-injection. Following a single dose of AGRP (86-132) (0.1 nmol) the increased food intake was sustained for 6 days, occurring in the light cycle of the first 2 days and subsequently switching to the dark cycle of the last 4 days. These time course profiles indicate the complexity of the mechanisms involved in AGRP-induced feeding.",

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AU - Lu, X. Y.

AU - Nicholson, J. R.

AU - Akil, H.

AU - Watson, S. J.

PY - 2001/5/8

Y1 - 2001/5/8

N2 - Agouti-related protein (AGRP) is a newly identified orexigenic peptide that acts as an endogenous antagonist of melanocortin receptors MC3 and MC4. The present study examined the time course of the orexigenic effects of synthetic AGRP (86-132). Intracerebroventricular infusion of 0.1 nmol AGRP (86-132) increased food intake by 450 ± 81% at 2h post-injection. A second increase in non-cumulative food intake (512 ± 135%) was observed at 6h post-injection. Following a single dose of AGRP (86-132) (0.1 nmol) the increased food intake was sustained for 6 days, occurring in the light cycle of the first 2 days and subsequently switching to the dark cycle of the last 4 days. These time course profiles indicate the complexity of the mechanisms involved in AGRP-induced feeding.

AB - Agouti-related protein (AGRP) is a newly identified orexigenic peptide that acts as an endogenous antagonist of melanocortin receptors MC3 and MC4. The present study examined the time course of the orexigenic effects of synthetic AGRP (86-132). Intracerebroventricular infusion of 0.1 nmol AGRP (86-132) increased food intake by 450 ± 81% at 2h post-injection. A second increase in non-cumulative food intake (512 ± 135%) was observed at 6h post-injection. Following a single dose of AGRP (86-132) (0.1 nmol) the increased food intake was sustained for 6 days, occurring in the light cycle of the first 2 days and subsequently switching to the dark cycle of the last 4 days. These time course profiles indicate the complexity of the mechanisms involved in AGRP-induced feeding.

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KW - Dark cycle

KW - Food intake

KW - Light cycle

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Time course of short-term and long-term orexigenic effects of Agouti-related protein (86-132)

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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