Time dependent decreases in central α7 nicotinic acetylcholine receptors associated with haloperidol and risperidone treatment in rats

Alvin V Terry, Debra A. Gearhart

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

α7 nicotinic acetylcholine receptor deficits may contribute to cognitive dysfunction in schizophrenia; however, the contribution of antipsychotic drug exposure to these deficits is unknown. In this study, rats were treated orally with haloperidol (2.0 mg/kg/day) or risperidone (2.5 mg/kg/day) for 15 or 90 days. Subsequent immunoassays indicated that both antipsychotics were associated with α7 nicotinic receptor decreases in the basal forebrain and prefrontal cortex when administered for 90 (but not 15) days, a result that was confirmed in autoradiographic experiments. These data suggest that haloperidol and risperidone may be associated with time dependent decreases in an important neurobiological substrate of memory.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalEuropean Journal of Pharmacology
Volume571
Issue number1
DOIs
StatePublished - Sep 24 2007

Fingerprint

Risperidone
Nicotinic Receptors
Haloperidol
Antipsychotic Agents
Prefrontal Cortex
Immunoassay
Schizophrenia
Cognitive Dysfunction
Basal Forebrain

Keywords

  • Acetylcholine
  • Antipsychotic
  • Cholinergic
  • Cognition
  • Memory
  • Schizophrenia

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

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