Time-dependent depotentiation in the dentate gyrus of freely moving rats by repeated brief 7 Hz stimulation

Thomas Straube, Julietta Uta Frey

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Long-term potentiation (LTP) in the hippocampus of awake animals is known to be reversed by long trains of low-frequency stimulation (LFS). Here we show that a persistent LTP reversal, i.e. depotentiation (DP), can be induced in the dentate gyrus of freely moving rats by brief 7 Hz stimulations (three trains of 100 pulses, 1 min intertrain-interval) if LFS was applied 2 min after tetanization. In contrast, the same LFS protocol given 15 min after tetanization failed to induce long-lasting DP. Likewise, reduction of LFS (given 2 min post-tetanus) to two trains resulted only in short-term DP. Because naturally occurring hippocampal 7 Hz oscillatory events are correlated to new sensory input, our results might be relevant for the understanding of the mechanisms of LTP reversal induced by processing new information.

Original languageEnglish (US)
Pages (from-to)82-84
Number of pages3
JournalNeuroscience Letters
Volume339
Issue number1
DOIs
StatePublished - Mar 13 2003

Keywords

  • Dentate gyrus
  • Depotentiation
  • Hippocampus
  • Long-term potentiation
  • Low-frequency stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

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