Time perception following unilateral amobarbital injection in patients with temporal lobe epilepsy

Daniel L. Drane, Gregory P Lee, David W. Loring, Kimford J. Meador

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Estimates of elapsed time were obtained from 53 patients with unilateral temporal lobe epilepsy (Left TLE = 27; Right TLE = 26) following Wada (intracarotid amobarbital) assessment. After resolution of drug effects, patients were asked to estimate how much time had passed since amobarbital administration. Estimates were also obtained from 24 healthy control subjects using the same cognitive tasks over a similar time frame. Elapsed time was significantly underestimated by both left and right TLE groups following right hemisphere injection. In addition, there was an interaction effect involving patient group, side of injection, and sequence of injection. Left TLE patients, consistent with normal controls, made more accurate time estimates when they could anticipate the estimation task following the second amobarbital administration. More accurate time estimates, however, occurred only when left hemisphere injection was second in sequence. In contrast, right TLE patients did not improve regardless of the order of injection. These results suggest that right hemisphere function plays a critical role in the accuracy of time estimations of intermediate temporal duration and that interhemispheric interaction may be required to make accurate retrospective temporal judgments. These findings are discussed in the context of the growing evidence for a right-hemispheric attentional network.

Original languageEnglish (US)
Pages (from-to)385-396
Number of pages12
JournalJournal of Clinical and Experimental Neuropsychology
Volume21
Issue number3
DOIs
StatePublished - Oct 4 1999

Fingerprint

Time Perception
Amobarbital
Temporal Lobe Epilepsy
Injections
Patient Rights
Healthy Volunteers

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychology(all)
  • Clinical Psychology

Cite this

Time perception following unilateral amobarbital injection in patients with temporal lobe epilepsy. / Drane, Daniel L.; Lee, Gregory P; Loring, David W.; Meador, Kimford J.

In: Journal of Clinical and Experimental Neuropsychology, Vol. 21, No. 3, 04.10.1999, p. 385-396.

Research output: Contribution to journalArticle

Drane, Daniel L. ; Lee, Gregory P ; Loring, David W. ; Meador, Kimford J. / Time perception following unilateral amobarbital injection in patients with temporal lobe epilepsy. In: Journal of Clinical and Experimental Neuropsychology. 1999 ; Vol. 21, No. 3. pp. 385-396.
@article{16babba98b5741979520fbb90780c638,
title = "Time perception following unilateral amobarbital injection in patients with temporal lobe epilepsy",
abstract = "Estimates of elapsed time were obtained from 53 patients with unilateral temporal lobe epilepsy (Left TLE = 27; Right TLE = 26) following Wada (intracarotid amobarbital) assessment. After resolution of drug effects, patients were asked to estimate how much time had passed since amobarbital administration. Estimates were also obtained from 24 healthy control subjects using the same cognitive tasks over a similar time frame. Elapsed time was significantly underestimated by both left and right TLE groups following right hemisphere injection. In addition, there was an interaction effect involving patient group, side of injection, and sequence of injection. Left TLE patients, consistent with normal controls, made more accurate time estimates when they could anticipate the estimation task following the second amobarbital administration. More accurate time estimates, however, occurred only when left hemisphere injection was second in sequence. In contrast, right TLE patients did not improve regardless of the order of injection. These results suggest that right hemisphere function plays a critical role in the accuracy of time estimations of intermediate temporal duration and that interhemispheric interaction may be required to make accurate retrospective temporal judgments. These findings are discussed in the context of the growing evidence for a right-hemispheric attentional network.",
author = "Drane, {Daniel L.} and Lee, {Gregory P} and Loring, {David W.} and Meador, {Kimford J.}",
year = "1999",
month = "10",
day = "4",
doi = "10.1076/jcen.21.3.385.922",
language = "English (US)",
volume = "21",
pages = "385--396",
journal = "Journal of Clinical and Experimental Neuropsychology",
issn = "0168-8634",
publisher = "Psychology Press Ltd",
number = "3",

}

TY - JOUR

T1 - Time perception following unilateral amobarbital injection in patients with temporal lobe epilepsy

AU - Drane, Daniel L.

AU - Lee, Gregory P

AU - Loring, David W.

AU - Meador, Kimford J.

PY - 1999/10/4

Y1 - 1999/10/4

N2 - Estimates of elapsed time were obtained from 53 patients with unilateral temporal lobe epilepsy (Left TLE = 27; Right TLE = 26) following Wada (intracarotid amobarbital) assessment. After resolution of drug effects, patients were asked to estimate how much time had passed since amobarbital administration. Estimates were also obtained from 24 healthy control subjects using the same cognitive tasks over a similar time frame. Elapsed time was significantly underestimated by both left and right TLE groups following right hemisphere injection. In addition, there was an interaction effect involving patient group, side of injection, and sequence of injection. Left TLE patients, consistent with normal controls, made more accurate time estimates when they could anticipate the estimation task following the second amobarbital administration. More accurate time estimates, however, occurred only when left hemisphere injection was second in sequence. In contrast, right TLE patients did not improve regardless of the order of injection. These results suggest that right hemisphere function plays a critical role in the accuracy of time estimations of intermediate temporal duration and that interhemispheric interaction may be required to make accurate retrospective temporal judgments. These findings are discussed in the context of the growing evidence for a right-hemispheric attentional network.

AB - Estimates of elapsed time were obtained from 53 patients with unilateral temporal lobe epilepsy (Left TLE = 27; Right TLE = 26) following Wada (intracarotid amobarbital) assessment. After resolution of drug effects, patients were asked to estimate how much time had passed since amobarbital administration. Estimates were also obtained from 24 healthy control subjects using the same cognitive tasks over a similar time frame. Elapsed time was significantly underestimated by both left and right TLE groups following right hemisphere injection. In addition, there was an interaction effect involving patient group, side of injection, and sequence of injection. Left TLE patients, consistent with normal controls, made more accurate time estimates when they could anticipate the estimation task following the second amobarbital administration. More accurate time estimates, however, occurred only when left hemisphere injection was second in sequence. In contrast, right TLE patients did not improve regardless of the order of injection. These results suggest that right hemisphere function plays a critical role in the accuracy of time estimations of intermediate temporal duration and that interhemispheric interaction may be required to make accurate retrospective temporal judgments. These findings are discussed in the context of the growing evidence for a right-hemispheric attentional network.

UR - http://www.scopus.com/inward/record.url?scp=0032880916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032880916&partnerID=8YFLogxK

U2 - 10.1076/jcen.21.3.385.922

DO - 10.1076/jcen.21.3.385.922

M3 - Article

VL - 21

SP - 385

EP - 396

JO - Journal of Clinical and Experimental Neuropsychology

JF - Journal of Clinical and Experimental Neuropsychology

SN - 0168-8634

IS - 3

ER -