Tissue oxygen distribution in head and neck cancer patients

Markus F. Adam, Edward C. Gabalski, Daniel A. Bloch, John W. Oehlert, J. Martin Brown, Amr A. Elsaid, Harlan A. Pinto, David J Terris

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

Background. The importance of hypoxia in limiting the sensitivity of tumor cells to ionizing radiation has long been known. Methods. We evaluated the tissue oxygenation status with a polarographic needle electrode system in 37 patients with malignancies of the head and neck and correlated the PO2 of 25 patients with treatment outcome. Results. Sixteen tumors contained areas of severe hypoxia, defined by pO~2 values below 2.5 mm Hg. Tumor oxygenation parameters were not correlated with hemoglobin, age, and his tory of tobacco use. There were no subcutaneous pO2 values below 10 mm Hg (ie, no areas of moderate or severe hypoxia), whereas this degree of hypoxia was commonly found in the tumors. Though not statistically significant, hypoxic tumors showed trends for poorer treatment outcome. Conclusion. Our data demonstrate a great interindividual variability in the oxygenation of head and neck cancers and appears unassociated with clinical parameters. The method is capable of identifying patients with poorly oxygenated tumors, thereby providing important information for selecting patients who might need customized therapy designed to kill hypoxic tumor cells. Hypoxic tumors show a consistent trend for poor treatment outcome.

Original languageEnglish (US)
Pages (from-to)146-153
Number of pages8
JournalHead and Neck
Volume21
Issue number2
DOIs
Publication statusPublished - Mar 1 1999
Externally publishedYes

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Keywords

  • Head and neck cancer
  • Neck nodes
  • Polarographic oxygen electrode
  • Treatment outcome
  • Tumor oxygenation

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Adam, M. F., Gabalski, E. C., Bloch, D. A., Oehlert, J. W., Brown, J. M., Elsaid, A. A., ... Terris, D. J. (1999). Tissue oxygen distribution in head and neck cancer patients. Head and Neck, 21(2), 146-153. https://doi.org/10.1002/(SICI)1097-0347(199903)21:2<146::AID-HED8>3.0.CO;2-U