Tissue penetration of clindamycin in diabetic foot infections

Charles Duckworth, John Fremont Fisher, Sally A. Carter, Cheryl L Newman, Cindy Cogburn, Robert R. Nesbit, Charles H. Wray

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Serum and tissue samples were obtained during surgery from four diabetics with neuropathy who underwent debridement or amputation for foot infections while receiving cindamycin 600 or 900 mg iv. Clindamycin concentrations were assayed by radioimmunoassay. Clindamycin was detected in all serum and tissue samples (range: 0·04-2·8 mg/kg in tissues and 1·1-11·1 mg/L in serum). In nine of the eleven tissue samples the clindamycin concentration exceeded the MICs reported for many pathogens commonly involved in such infections. In only a single instance was the ratio of tissue to serum concentration < 0·13.

Original languageEnglish (US)
Pages (from-to)581-584
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume31
Issue number4
DOIs
StatePublished - Apr 1 1993

Fingerprint

Diabetic Foot
Clindamycin
Infection
Serum
Diabetic Neuropathies
Debridement
Amputation
Radioimmunoassay
Foot

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Tissue penetration of clindamycin in diabetic foot infections. / Duckworth, Charles; Fisher, John Fremont; Carter, Sally A.; Newman, Cheryl L; Cogburn, Cindy; Nesbit, Robert R.; Wray, Charles H.

In: Journal of Antimicrobial Chemotherapy, Vol. 31, No. 4, 01.04.1993, p. 581-584.

Research output: Contribution to journalArticle

Duckworth, Charles ; Fisher, John Fremont ; Carter, Sally A. ; Newman, Cheryl L ; Cogburn, Cindy ; Nesbit, Robert R. ; Wray, Charles H. / Tissue penetration of clindamycin in diabetic foot infections. In: Journal of Antimicrobial Chemotherapy. 1993 ; Vol. 31, No. 4. pp. 581-584.
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